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Merck
CN

762334

Diethyl methylphosphonite

97%, liquid

Synonym(s):

Diethoxymethylphosphine

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About This Item

Empirical Formula (Hill Notation):
C5H13O2P
CAS Number:
15715-41-0
Molecular Weight:
136.13
NACRES:
NA.22
PubChem Substance ID:
329766965
UNSPSC Code:
12352108
EC Number:
239-805-9
MDL number:
MFCD00009089

Key Documents

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Product Name

Diethyl methylphosphonite, 97%

InChI key

NSSMTQDEWVTEKN-UHFFFAOYSA-N

InChI

1S/C5H13O2P/c1-4-6-8(3)7-5-2/h4-5H2,1-3H3

SMILES string

CCOP(C)OCC

assay

97%

form

liquid

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Hiyama Coupling, reaction type: Negishi Coupling, reaction type: Sonogashira Coupling, reaction type: Stille Coupling, reaction type: Suzuki-Miyaura Coupling, reagent type: ligand

refractive index

n20/D 1.419

density

0.907 g/mL at 25 °C

storage temp.

2-8°C

Quality Level

100

Application

Diethyl methylphosphonite can be used as a mild reducing reagent in the oxalimide cyclization of oxalylazetidinonyl thiocarbonates and thioesters. It can also be used in the synthesis of β-carboxamido-phosphon(in)ic acids as potential inhibitors of human mast cell chymase.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

hcodes

H226,H302

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 3

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

84.9 °F

flash_point_c

29.4 °C

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
MKCD5671
MKBW1898V
MKBT8338V
MKBQ7060V
MKBN2457V

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Alkylphosphonous acid diesters, novel reagents for the oxalimide cyclization to penems.
Budt K H, et al.
Tetrahedron Letters, 33(37), 5331-5334 (1992)
Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.
Greco M N, et al.
Journal of Medicinal Chemistry, 50(8), 1727-1730 (2007)

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