764191
Alkyne-PEG5-N-hydroxysuccinimidyl ester
Synonym(s):
Acetylene-PEG5-NHS ester, Alkyne-PEG5-NHS ester, Alkyne-PEG5-succinimidyl ester
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About This Item
Empirical Formula (Hill Notation):
C18H27NO9
Molecular Weight:
401.41
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352108
MDL number:
Form:
liquid
InChI
1S/C18H27NO9/c1-2-6-23-8-10-25-12-14-27-15-13-26-11-9-24-7-5-18(22)28-19-16(20)3-4-17(19)21/h1H,3-15H2
SMILES string
C#CCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O
InChI key
ACZDUKRWTPZVRP-UHFFFAOYSA-N
form
liquid
reaction suitability
reaction type: click chemistry
reagent type: cross-linking reagent
functional group
NHS ester
alkyne
storage temp.
−20°C
Quality Level
Application
Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a primary amine. The succinimidyl ester group will react preferentially with primary amines to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification amine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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