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Merck
CN

764590

Poly(L-lactide)

average Mn 5,000, PDI ≤1.2

Synonym(s):

PLLA, Polylactide, L-Lactide polymer, PLA, Poly(L-Lactic acid)

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About This Item

Linear Formula:
H(C3H4O2)nOCH3
NACRES:
NA.23
UNSPSC Code:
12162002

Key Documents

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Product Name

Poly(L-lactide), average Mn 5,000, PDI ≤1.2

form

solid

optical activity

[α]22/D -147°, c = 0.5% in chloroform

mol wt

average Mn 5,000

degradation timeframe

>3 years

transition temp

Tm 149-154 °C

PDI

≤1.2

storage temp.

2-8°C

Quality Level

100

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Features and Benefits

High initial strength, good strength retention and high amount of crystallinity as much as 70% which in turn is responsible for the very slow degradation rate.

Application

Drug Delivery including coating nanoparticles;end-group functionalization ;macroinitiator or block precursor.

General description

Poly (L-lactide) is a semi-crystalline polymer which exhibits strong optical rotation and good mechanical properties. It is mostly used in the synthesis of degradable polymers which are used in orthopaedic devices, in dental applications, as scaffolds for autografted new skin, wound covers, anastomose systems and stents. They are biodegradable since the polyester backbone degrades by simple hydrolysis to form non-toxic compounds.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX2154
MKCX2156
MKCN1974
MKCK4339
MKCH2480

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Chemical synthesis of polylactide and its copolymers for medical applications
Bendix, D.
Polymer Degradation and Stability, 59(1), 129-135 (1998)
Effect of poly (ethylene glycol)-block- poly (L-lactide) on the poly [(R)-3-hydroxybutyrate]/poly (L-lactide) blends
Yoon, J. S., Lee, W. S., Kim, K. S., Chin, I. J., Kim, M. N., & Kim, C.
Eur. Polymer J., 36(2), 435-442 (2000)
Synthesis and thermal properties of novel star-shaped poly (l-lactide)s with starburst PAMAM-OH dendrimer macroinitiator.
Zhao, Y. L., Cai, Q., Jiang, J., Shuai, X. T., Bei, J. Z., Chen, C. F., & Xi, F.
Polymer, 43(22), 5819-5825 (2002)
Zhang, Wen-Bin; et al.
Macromolecules, 44, 2589-2596 (2011)
Wolf, Florian F.; et al.
Macromolecules, 42, 5622-5628 (2009)
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