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779873

Methyl-β-cyclodextrin

Name: Methyl-β-cyclodextrin
Brand: ALDRICH

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, ≥98.0% cyclodextrin basis

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Synonym(s):

Cavasol^® W7 M Life Science, MβCD, Methyl-beta-cyclodextrin

CAS Number:

128446-36-6

NACRES:

NA.22

grade

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science

Assay

≥98.0% cyclodextrin basis

form

powder

optical activity

[α]/D 154.0 to 156.0°

mol wt

M_w 1310 g/mol

extent of labeling

1.7-1.9 molar substitution

impurities

≤0.10% unsubstituted cyclodextrin
≤0.20% chloride
≤0.50% reducing substances
≤50 ppm volatile organics

ign. residue

≤0.50%

loss

≤5.0% loss on drying

color

white to off-white

mp

180-182 °C (lit.)

absorption

≤0.10 at 350-600 nm in solution at 10%
≤1.00 at 220-350 nm in solution at 10%

InChI

1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3

InChI key

QGKBSGBYSPTPKJ-UHFFFAOYSA-N

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Related Categories

Carbohydrates for Biochemical Research

Application

Methyl-β-cyclodextrin is a macrocyclic compound that can form inclusion complexes with a number of guest molecules. It shows higher solubility in aqueous solutions and greater solubilizing and complexing power compared to the parent β-cyclodextrin. MβCD can be used to enhance the enzyme activity and enantioselectivity of subtilisin enzyme in organic solvents.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

For R&D Use

Legal Information

Cavasol is a registered trademark of Wacker Chemie AG

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

368.6 °F

Flash Point(C)

187 °C

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Preparation and solid-state characterization of inclusion complexes formed between miconazole and methyl-?-cyclodextrin.

Ribeiro A

Aaps Pharmscitech, 9(4), 1102-1109 (2008)

Improved enzyme activity and enantioselectivity in organic solvents by methyl-?-cyclodextrin.

Griebenow K

Journal of the American Chemical Society, 121(36), 8157-8163 (1999)

Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line.

Sara Rodríguez-Acebes et al.

The Biochemical journal, 420(2), 305-315 (2009-03-06)

Cholesterol homoeostasis is critical for cell viability and proliferation. The SREBP (sterol regulatory element-binding protein) pathway is crucial for the maintenance of cholesterol homoeostasis. This pathway is controlled by cholesterol and cholesterol-derived oxysterols. J774 cells cannot convert desmosterol into cholesterol

Expression and shedding of endothelial protein C receptor in prostate cancer cells.

Mario Menschikowski et al.

Cancer cell international, 11, 4-4 (2011-02-16)

Increasing evidences show that beyond its role in coagulation, endothelial protein C receptor (EPCR) interferes with carcinogenesis. Pro-carcinogenic effects of EPCR were linked with a raised generation of activated protein C (aPC) and anti-apoptotic signalling. This study was carried out

Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.

Laurie Hamtiaux et al.

PloS one, 6(10), e26823-e26823 (2011-11-03)

The antitumoral properties of endocannabinoids received a particular attention these last few years. Indeed, these endogenous molecules have been reported to exert cytostatic, apoptotic and antiangiogenic effects in different tumor cell lines and tumor xenografts. Therefore, we investigated the cytotoxicity

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