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Merck
CN

78110

Sigma-Aldrich

Phe-Gly hydrate

≥98.0% (dried material)

Synonym(s):

L-Phenylalanyl-glycine hydrate

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About This Item

Linear Formula:
C6H5CH2CH(NH2)CONHCH2COOH · aq
CAS Number:
721-90-4
Molecular Weight:
222.24 (anhydrous basis)
Beilstein:
2218143
MDL number:
MFCD00150303
UNSPSC Code:
12352200
PubChem Substance ID:
57652723

Key Documents

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Quality Level

100

Assay

≥98.0% (dried material)

form

crystals

optical activity

[α]20/D +103±3°, c = 1% in H2O

impurities

≤5% ethanol
≤5% water

mp

~260 °C (dec.)

application(s)

peptide synthesis

SMILES string

O.N[C@@H](Cc1ccccc1)C(=O)NCC(O)=O

InChI

1S/C11H14N2O3.H2O/c12-9(11(16)13-7-10(14)15)6-8-4-2-1-3-5-8;/h1-5,9H,6-7,12H2,(H,13,16)(H,14,15);1H2/t9-;/m0./s1

InChI key

QNLAQUFDXQTNOW-FVGYRXGTSA-N

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBQ1406V
BCBK9641V
1308786
1286771
424048/1

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Claire E Atkinson et al.
Biophysical journal, 104(1), 37-50 (2013-01-22)
Selective transport through the nuclear pore complex (NPC) requires nucleoporins containing natively unfolded phenylalanine-glycine (FG) domains. Several differing models for their dynamics within the pore have been proposed. We characterize the behavior of the FG nucleoporins in vivo using polarized fluorescence
S Chakrabarti et al.
Toxicology, 67(1), 15-27 (1991-03-25)
An isomeric mixture of S-[(1 and 2)-phenyl-2-hydroxyethyl]glutathione (PHEG), a glutathione conjugate of styrene, is moderately nephrotoxic. Its in vivo nephrotoxicity was characterized by significant elevations in the urinary excretion of glucose, gamma-glutamyl transpeptidase, glutamate dehydrogenase, N-acetyl-beta-D-glucosaminidase and lactic dehydrogenase 24
Akira Yamamoto et al.
International journal of pharmaceutics, 250(1), 119-128 (2002-12-14)
We synthesized three novel lipophilic derivatives of phenylalanyl-glycine (Phe-Gly), C4-Phe-Gly, C6-Phe-Gly and C8-Phe-Gly by chemical modification with butyric acid (C4), caproic acid (C6) and octanoic acid (C8). The effect of the acylation on the stability, permeability and accumulation of Phe-Gly
Eun-Kyung Suh et al.
Experimental cell research, 290(2), 447-456 (2003-10-22)
beta-Catenin nuclear import has been found to be independent of classical nuclear localization signal (NLS) nuclear import factors. Here, we test the hypothesis that beta-catenin interacts directly with nuclear pore proteins to mediate its own transport. We show that beta-catenin
Jon Våbenø et al.
Journal of medicinal chemistry, 47(4), 1060-1069 (2004-02-06)
A series of five Phe-Gly dipeptidomimetics containing different amide bond replacements have been synthesized in a facile way from the readily available unsaturated ketoester 1, and their affinities for the di-/tripeptide transporters hPEPT1 (Caco-2 cells) and rPEPT2 (SKPT cells) were
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