79224
1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-one
≥96.0% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C13H17N3O
CAS Number:
Molecular Weight:
231.29
EC Number:
213-819-5
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
617685
MDL number:
InChI key
HTQWGIHCFPWKAS-UHFFFAOYSA-N
InChI
1S/C13H17N3O/c17-12-13(6-8-14-9-7-13)16(10-15-12)11-4-2-1-3-5-11/h1-5,14H,6-10H2,(H,15,17)
SMILES string
O=C1NCN(c2ccccc2)C13CCNCC3
assay
≥96.0% (HPLC)
mp
188-191 °C
storage temp.
2-8°C
Gene Information
rat ... Htr1a(24473), Htr2a(29595), Htr2c(25187)
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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T Araki et al.
Neuroreport, 5(1), 37-40 (1993-10-25)
Using quantitative receptor autoradiography, spirodecanone binding was evaluated in the gerbil hippocampus 1 h-1 month after cerebral ischaemia of 10 min. The spirodecanone binding was unaffected in the hippocampus up to 48 h after ischaemia. Thereafter, increased binding was found
F Murakami et al.
Pharmacology, 49(5), 286-295 (1994-11-01)
We investigated the effects of vinconate and pentobarbital against the alterations in spirodecanone binding in the gerbil striatum and hippocampus 5 h and 7 days after 10 min of cerebral ischemia, using receptor autoradiography. Vinconate and pentobarbital were given intraperitoneally
A Bruinink et al.
Journal of neurochemistry, 40(5), 1227-1236 (1983-05-01)
The ontogeny of binding sites for [3H] spiperone was studied in time-pregnant rats. Binding of [3H]spiperone to fresh homogenates of pre- and postnatal rat forebrain was characterized by Scatchard analysis and competition experiments with a number of dopaminergic and serotonergic
P M Laduron
Biochemical pharmacology, 37(1), 37-40 (1988-01-01)
In binding studies, stereospecificity is not a property restricted to receptor sites; indeed stereospecific binding has also been observed for acceptor sites. Therefore it does not represent a decisive criterion to make a binding site, a receptor site. However, in
H Onodera et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 8(4), 568-574 (1988-08-01)
Opioid ([3H]naloxone) and spirodecanone ([3H]spiperone) binding sites in the hippocampus were visualized in the Mongolian gerbil and in the rat using in vitro autoradiography. In the hippocampus, marked differences were noted in the stratum (sr.) pyramidale of the CA1 subfield
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