79224
1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-one
≥96.0% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C13H17N3O
CAS Number:
Molecular Weight:
231.29
Beilstein:
617685
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
Assay
≥96.0% (HPLC)
mp
188-191 °C
storage temp.
2-8°C
SMILES string
O=C1NCN(c2ccccc2)C13CCNCC3
InChI
1S/C13H17N3O/c17-12-13(6-8-14-9-7-13)16(10-15-12)11-4-2-1-3-5-11/h1-5,14H,6-10H2,(H,15,17)
InChI key
HTQWGIHCFPWKAS-UHFFFAOYSA-N
Gene Information
rat ... Htr1a(24473), Htr2a(29595), Htr2c(25187)
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Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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A Bruinink et al.
Journal of neurochemistry, 40(5), 1227-1236 (1983-05-01)
The ontogeny of binding sites for [3H] spiperone was studied in time-pregnant rats. Binding of [3H]spiperone to fresh homogenates of pre- and postnatal rat forebrain was characterized by Scatchard analysis and competition experiments with a number of dopaminergic and serotonergic
F Murakami et al.
Pharmacology, 49(5), 286-295 (1994-11-01)
We investigated the effects of vinconate and pentobarbital against the alterations in spirodecanone binding in the gerbil striatum and hippocampus 5 h and 7 days after 10 min of cerebral ischemia, using receptor autoradiography. Vinconate and pentobarbital were given intraperitoneally
Differentiation of solubilized dopamine receptors from spirodecanone binding sites in rat striatum.
H Gorissen et al.
FEBS letters, 121(1), 133-138 (1980-11-17)
T Araki et al.
Neuroreport, 5(1), 37-40 (1993-10-25)
Using quantitative receptor autoradiography, spirodecanone binding was evaluated in the gerbil hippocampus 1 h-1 month after cerebral ischaemia of 10 min. The spirodecanone binding was unaffected in the hippocampus up to 48 h after ischaemia. Thereafter, increased binding was found
P M Laduron
Biochemical pharmacology, 37(1), 37-40 (1988-01-01)
In binding studies, stereospecificity is not a property restricted to receptor sites; indeed stereospecific binding has also been observed for acceptor sites. Therefore it does not represent a decisive criterion to make a binding site, a receptor site. However, in
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