797278
Cy3-TPG
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About This Item
Empirical Formula (Hill Notation):
C43H48N6O12S3
Molecular Weight:
937.07
PubChem Substance ID:
UNSPSC Code:
12352200
form
solid
SMILES string
CC1(C)C(/C=C/C=C2N(CCCS(O)(=O)=O)C3=CC=C(S(=O)(O)=O)C=C3C/2(C)C)=[N+](CCCCCC(NCC4=CN(C5=CC=C(C(C([H])=O)=O)C=C5)N=N4)=O)C6=C1C=C(S(=O)([O-])=O)C=C6
InChI
1S/C43H48N6O12S3/c1-42(2)34-24-32(63(56,57)58)17-19-36(34)47(21-7-5-6-12-41(52)44-26-30-27-49(46-45-30)31-15-13-29(14-16-31)38(51)28-50)39(42)10-8-11-40-43(3,4)35-25-33(64(59,60)61)18-20-37(35)48(40)22-9-23-62(53,54)55/h8,10-11,13-20,24-25,27-28H,5-7,9,12,21-23,26H2,1-4H3,(H3-,44,52,53,54,55,56,57,58,59,60,61)
InChI key
CPPSEGLVNJSTIR-UHFFFAOYSA-N
Application
This compound is for specifically labeling arginines with Cy3. The compound contains a phenylglyoxyl group that reacts specifically with the guanidinyl group of arginine. After attachment to arginine the Cy3 can be detected by measuring fluorescence. Unmodified Cy3 has an excitation at ~550 nm and an emission at ~570 nm. See the associated publication by Thompson et al. for more details about the compound.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Darren A Thompson et al.
Journal of peptide science : an official publication of the European Peptide Society, 22(5), 311-319 (2016-03-24)
A new class of arginine-specific bioconjugation reagents for protein labeling has been developed. This method utilizes a triazolyl-phenylglyoxal group on the probe molecule that reacts selectively with the guandinyl group of Arg residues in a protein or peptide. The reaction