803669
SIAB (N-succinimidyl (4-iodoacetyl)aminobenzoate)
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About This Item
Empirical Formula (Hill Notation):
C13H11N2O5I
CAS Number:
Molecular Weight:
402.14
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C13H11IN2O5/c14-7-10(17)15-9-3-1-8(2-4-9)13(20)21-16-11(18)5-6-12(16)19/h1-4H,5-7H2,(H,15,17)
SMILES string
O=C(CCC1=O)N1OC(C2=CC=C(NC(CI)=O)C=C2)=O
InChI key
BQWBEDSJTMWJAE-UHFFFAOYSA-N
assay
≥95%
form
powder
mol wt
402.15
reaction suitability
reagent type: cross-linking reagent
storage condition
desiccated
solubility
DMSO or DMF: soluble
functional group
NHS ester
shipped in
ambient
storage temp.
2-8°C
Features and Benefits
- Reactive groups: NHS ester and iodoacetyl
- Reactive toward: amino and sulfhydryl groups
- Non-cleavable
- Water-insoluble (dissolve first in DMF or DMSO); compare to Sulfo-SIAB
- Used to prepare stable enzyme-IgG conjugates
- Forms conjugates with liposomes
Disclaimer
This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.
General description
SIAB is an amine- and sulfhydryl-reactive heterobifunctional crosslinker and Sulfo-SIAB is its water-soluble analog. These crosslinkers contain an amine-reactive N-hydroxysuccimide (NHS) ester and a sulfhydryl-reactive iodoacetyl group, and are often used for preparing enzyme conjugates or immunotoxins. Water-soluble and water-insoluble forms of NHS esters have essentially identical reactivity. Sulfo-SIAB is supplied as a sodium salt and is water-soluble to ~10mM. SIAB must be first dissolved in an organic solvent, such as DMSO or DMF, and then added to the aqueous reaction mixture. SIAB is lipophilic, membrane-permeable and does not possess a charged group.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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