806382
Poly(N-isopropylacrylamide)
carboxylic acid terminated
Synonym(s):
NIPAM polymer, PNIPAM, functionalized polyNIPAM
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About This Item
Empirical Formula (Hill Notation):
C4H7O2(C6H11NO)nH
NACRES:
NA.23
UNSPSC Code:
12162002
form
powder
mol wt
average Mw 10,000
PDI
<1.3
storage temp.
2-8°C
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Application
PolyNIPAM is a stimuli-responsive polymer. The low PDI means that the distribution of chain lengths is narrow which will typically lead to better reproducibility. This polymer for development of thermosensitive coated micro/nano materials including thermoresponsive polymeric drug delivery systems. The carboxylic acid functional group can be used to conjugate a variety of biomolecules to the polymer chain.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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W L Hinrichs et al.
Journal of controlled release : official journal of the Controlled Release Society, 60(2-3), 249-259 (1999-07-30)
Copolymers of 2-(dimethylamino) ethyl methacrylate (DMAEMA) and N-isopropylacryl amide (NIPAAm) of various monomer ratios and molecular weights were evaluated as carrier systems for DNA delivery. All copolymers, even with a low DMAEMA content of 15 mol%, were able to bind
Ravin Narain et al.
Langmuir : the ACS journal of surfaces and colloids, 23(11), 6299-6304 (2007-04-25)
We describe here the synthesis of 10 nm, monodisperse, iron oxide nanoparticles that we have coated with temperature-sensitive, biotinylated p(NIPAAm) (b-PNIPAAm). The PNIPAAm was prepared by the reversible addition fragmentation chain transfer polymerization (RAFT), and one end was biotinylated with
J E Chung et al.
Journal of controlled release : official journal of the Controlled Release Society, 62(1-2), 115-127 (1999-10-16)
To achieve a combination of spatial specificity in a passive manner with a stimuli-responsive targeting mechanism, a temperature-responsive polymeric micelle is prepared using block copolymers of (poly(N-isopropylacrylamide-b-butylmethacrylate) (PIPAAm-PBMA)). The micelle inner core formed by self-aggregates of PBMA segments successfully loaded
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