852279
2′-Deoxyinosine
99%
Synonym(s):
9-(2-Deoxy-β-D-ribofuranosyl)hypoxanthine
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About This Item
Empirical Formula (Hill Notation):
C10H12N4O4
CAS Number:
Molecular Weight:
252.23
EC Number:
212-964-1
UNSPSC Code:
12352103
PubChem Substance ID:
Beilstein/REAXYS Number:
33517
MDL number:
Assay:
99%
Form:
powder
InChI key
VGONTNSXDCQUGY-RRKCRQDMSA-N
InChI
1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3C(=O)NC=Nc23
assay
99%
form
powder
functional group
ether, hydroxyl
Quality Level
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Manabu Yasui et al.
Journal of molecular biology, 377(4), 1015-1023 (2008-02-29)
Chronic inflammation involving constant generation of nitric oxide (*NO) by macrophages has been recognized as a factor related to carcinogenesis. At the site of inflammation, nitrosatively deaminated DNA adducts such as 2'-deoxyinosine (dI) and 2'-deoxyxanthosine are primarily formed by *NO
Bernard Weiss
DNA repair, 7(2), 205-212 (2007-11-06)
Deoxyinosine (dI) is produced in DNA by the hydrolytic or nitrosative deamination of deoxyadenosine. It is excised in a repair pathway that is initiated by endonuclease V, the product of the nfi gene. The repair was studied in vivo using
Rongjuan Mi et al.
Mutation research, 735(1-2), 12-18 (2012-06-06)
The human endonuclease V gene is located in chromosome 17q25.3 and encodes a 282 amino acid protein that shares about 30% sequence identity with bacterial endonuclease V. This study reports biochemical properties of human endonuclease V with respect to repair
Nobuyuki Horinouchi et al.
Applied microbiology and biotechnology, 71(5), 615-621 (2005-11-12)
2'-Deoxyribonucleosides are important as building blocks for the synthesis of antisense drugs, antiviral nucleosides, and 2'-deoxyribonucleotides for polymerase chain reaction. The microbial production of 2'-deoxyribonucleosides from simple materials, glucose, acetaldehyde, and a nucleobase, through the reverse reactions of 2'-deoxyribonucleoside degradation
Susen Hartmann et al.
Clinical chemistry, 52(6), 1127-1137 (2006-04-15)
Clinical presentation and disease severity in disorders of purine and pyrimidine metabolism vary considerably. We present a method that allows comprehensive, sensitive, and specific diagnosis of the entire spectrum of abnormalities in purine and pyrimidine metabolism in 1 analytical run.
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