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852589

5-(Hydroxymethyl)uracil

Name: 5-(Hydroxymethyl)uracil
Brand: ALDRICH

97%

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About This Item

Empirical Formula (Hill Notation):

C₅H₆N₂O₃

CAS Number:

4433-40-3

Molecular Weight:

142.11

NACRES:

NA.22

PubChem Substance ID:

24888325

UNSPSC Code:

12352100

EC Number:

224-636-5

MDL number:

MFCD00006070

Assay:

97%

Form:

powder

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Properties

Quality Level

200

assay

97%

form

powder

mp

>300 °C (lit.)

functional group

hydroxyl

SMILES string

[H]O[H].OCC1=CNC(=O)NC1=O

InChI

1S/C5H6N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1,8H,2H2,(H2,6,7,9,10)

InChI key

JDBGXEHEIRGOBU-UHFFFAOYSA-N

Description

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000510165

0000501585

0000465424

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Identification of high excision capacity for 5-hydroxymethyluracil mispaired with guanine in DNA of Escherichia coli MutM, Nei and Nth DNA glycosylases.

Masaki Hori et al.

Nucleic acids research, 31(4), 1191-1196 (2003-02-13)

The oxidation and deamination of 5-methylcytosine (5mC) in DNA generates a base-pair between 5-hydroxymethyluracil (5hmU) and guanine. 5hmU normally forms a base-pair with adenine. Therefore, the conversion of 5mC to 5hmU is a potential pathway for the generation of 5mC

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation.

Hideharu Hashimoto et al.

Nucleic acids research, 40(11), 4841-4849 (2012-03-01)

Cytosine residues in mammalian DNA occur in at least three forms, cytosine (C), 5-methylcytosine (M; 5mC) and 5-hydroxymethylcytosine (H; 5hmC). During semi-conservative DNA replication, hemi-methylated (M/C) and hemi-hydroxymethylated (H/C) CpG dinucleotides are transiently generated, where only the parental strand is

Diet is not responsible for the presence of several oxidatively damaged DNA lesions in mouse urine.

Rafal Rozalski et al.

Free radical research, 38(11), 1201-1205 (2004-12-29)

In order to eliminate the possibility that diet may influence urinary oxidative DNA lesion levels, in our experiments we used a recently developed technique involving HPLC pre-purification followed by gas chromatography with isotope dilution mass spectrometric detection. This methodology was

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Global Trade Item Number

SKU	GTIN
852589-1G-A	04061826219072