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Merck
CN

857661

4-Aminobenzamidine dihydrochloride

98%

Synonym(s):

p-Aminobenzimidamide dihydrochloride

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About This Item

Linear Formula:
H2NC6H4C(=NH)NH2·2HCl
CAS Number:
Molecular Weight:
208.09
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
219-692-2
Beilstein/REAXYS Number:
3692927
MDL number:
Assay:
98%
Form:
crystals
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Quality Level

assay

98%

form

crystals

mp

>300 °C (lit.)

functional group

amine

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].NC(=N)c1ccc(N)cc1

InChI

1S/C7H9N3.2ClH/c8-6-3-1-5(2-4-6)7(9)10;;/h1-4H,8H2,(H3,9,10);2*1H

InChI key

GHEHNICLPWTXJC-UHFFFAOYSA-N

Application

4-Aminobenzamidine dihydrochloride can be used to synthesize:
  • Orally active fibrinogen receptor antagonists based on benzamidines.
  • Benzamidine derivatives that are selective and potent serine protease inhibitors.
  • Novel pyrrolo [3,2-c] quinolines that are structural analogs of topoisomerase inhibitors such as coralyne and fagaronine.

4-Aminobenzamidine dihydrochloride is used as a ligand in affinity chromatography for purification and immobilization of enzymes.


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Design of orally active, non-peptide fibrinogen receptor antagonists. An evolutionary process from the RGD sequence to novel anti-platelet aggregation agents.
Bovy P R, et al.
Bioorganic & Medicinal Chemistry, 2(9), 881-895 (1994)
In vitro blood compatibility of polymeric biomaterials through covalent immobilization of an amidine derivative.
Gouzy M F, et al.
Biomaterials, 25(17), 3493-3501 (2004)
Biochemical and molecular modeling analysis of the ability of two p-aminobenzamidine-based sorbents to selectively purify serine proteases (fibrinogenases) from snake venoms.
De-Simone S G, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 822(1-2), 1-9 (2005)



Global Trade Item Number

SKUGTIN
857661-10G04061833032305
857661-1G04061825769004
857661-50G04061832107608