858900
L-Aspartyl-L-phenylalanine methyl ester
96%
Synonym(s):
N-L-α-Aspartyl-L-phenylalanine methyl ester, Asp-Phe methyl ester, Aspartame
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About This Item
Linear Formula:
HOOCCH2CH(NH2)CONHCH(CH2C6H5)COOCH3
CAS Number:
Molecular Weight:
294.30
EC Number:
245-261-3
UNSPSC Code:
12352103
PubChem Substance ID:
Beilstein/REAXYS Number:
2223850
MDL number:
InChI key
IAOZJIPTCAWIRG-QWRGUYRKSA-N
InChI
1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1
SMILES string
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(O)=O
assay
96%
mp
248-250 °C (lit.)
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Jean-Daniel Berset et al.
Chemosphere, 88(5), 563-569 (2012-04-17)
A HPLC-MS/MS method is presented for the simultaneous determination of frequently used artificial sweeteners (ASs) and the main metabolite of aspartame (ASP), diketopiperazine (DKP), in environmental water samples using the direct-injection (DI) technique, thereby achieving limits of quantification (LOQ) of
Eva S Schernhammer et al.
The American journal of clinical nutrition, 96(6), 1419-1428 (2012-10-26)
Despite safety reports of the artificial sweetener aspartame, health-related concerns remain. We prospectively evaluated whether the consumption of aspartame- and sugar-containing soda is associated with risk of hematopoetic cancers. We repeatedly assessed diet in the Nurses' Health Study (NHS) and
Maria Maersk et al.
The American journal of clinical nutrition, 95(2), 283-289 (2011-12-30)
The consumption of sucrose-sweetened soft drinks (SSSDs) has been associated with obesity, the metabolic syndrome, and cardiovascular disorders in observational and short-term intervention studies. Too few long-term intervention studies in humans have examined the effects of soft drinks. We compared
M Maersk et al.
European journal of clinical nutrition, 66(4), 523-529 (2012-01-19)
Observational studies indicate that sugar-sweetened soft drinks (SSSD) may promote obesity, among other factors, owing to low-satiating effects. The effect of energy in drinks on appetite is still unclear. We examined the effect of two isocaloric, but macronutrient, different beverages
Maartje C P Geraedts et al.
Molecular nutrition & food research, 56(3), 417-424 (2012-03-02)
Exposing the intestine to proteins or tastants, particularly sweet, affects satiety hormone release. There are indications that each sweetener has different effects on this release, and that combining sweeteners with other nutrients might exert synergistic effects on hormone release. STC-1
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