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Merck
CN

86020

Sulfacetamide sodium salt monohydrate

≥98.0% (dried material, T)

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About This Item

Empirical Formula (Hill Notation):
C8H9N2NaO3S · H2O
CAS Number:
Molecular Weight:
254.24
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
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InChI

1S/C8H10N2O3S.Na.H2O/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8;;/h2-5H,9H2,1H3,(H,10,11);;1H2/q;+1;/p-1

SMILES string

NC1=CC=C(S(N([Na])C(C)=O)(=O)=O)C=C1.O

InChI key

IHCDKJZZFOUARO-UHFFFAOYSA-M

assay

≥98.0% (dried material, T)

impurities

~7% water

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma

mode of action

enzyme | inhibits

General description

Chemical structure: sulfonamide

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Shmuel Graffi et al.
European journal of ophthalmology, 22(5), 834-835 (2012-01-24)
To report an unusual case of a patient with endogenous endophthalmitis caused by Actinomyces neuii. A 69-year-old woman in an immunosuppressed state and who had a previous history of periappendicular abscess presented with bilateral red painful eyes. The diagnosis was
Praveen N Naik et al.
Biopharmaceutics & drug disposition, 31(2-3), 120-128 (2010-01-15)
The binding of sulfacetamide sodium (SAS) to bovine serum albumin (BSA) was investigated by spectroscopic methods, namely fluorescence, FT-IR and UV-vis absorption spectral studies. The binding parameters were evaluated by a fluorescence quenching method. The thermodynamic parameters, DeltaH(0), DeltaS(0)and DeltaG(0)
Bivash Mandal et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 13(4), 510-523 (2010-01-01)
Polymeric nanosuspension was prepared from an inert polymer resin (Eudragit® RL100) with the aim of improving the availability of sulfacetamide at the intraocular level to combat bacterial infections. Nanosuspensions were prepared by the solvent displacement method using acetone and Pluronic®
A Parodi et al.
Annales de dermatologie et de venereologie, 138 Suppl 3, S211-S214 (2012-01-04)
A range of treatment options are available in rosacea, which include several topical (mainly metronidazole, azelaic acid, other antibiotics, sulfur, retinoids) and oral drugs (mainly tetracyclines, metronidazole, macrolides). In some cases, the first choice is a systemic therapy because patients
Yaxian Zhen et al.
Journal of drugs in dermatology : JDD, 6(8), 810-816 (2007-09-04)
Topical therapies are effective in managing acne vulgaris but are associated with local adverse effects such as irritation and dryness. This 4-week pilot study compared skin hydration in 36 healthy adult women randomized to treatment with 1 of 4 topical

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