860832
2-Thiocytidine dihydrate
98%
SMILES string
NC1=NC(=S)N(C=C1)[C@H]2O[C@H](CO)[C@@H](O)[C@H]2O
assay
98%
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Hans K Lundgren et al.
Journal of bacteriology, 188(8), 3052-3062 (2006-04-06)
The cysteine desulfurase IscS in Salmonella enterica serovar Typhimurium is required for the formation of all four thiolated nucleosides in tRNA, which is thought to occur via two principally different biosynthetic pathways. The synthesis of 4-thiouridine (s(4)U) and 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U)
R L Joshi et al.
FEBS letters, 208(2), 189-193 (1986-11-24)
A new approach for the fluorescence labeling of an aminoacyl-tRNA at the 3'-end is applied to study its interaction with bacterial elongation factor Tu (EF-Tu) and GTP at equilibrium. The penultimate cytidine residue in yeast tRNATyr-C-C-A was replaced by 2-thiocytidine
T Döring et al.
The EMBO journal, 13(11), 2677-2685 (1994-06-01)
A photo-reactive diazirine derivative was attached to the 2-thiocytidine residue at position 32 of tRNA(Arg)I from Escherichia coli. This modified tRNA was bound under suitable conditions to the A, P or E site of E.coli ribosomes. After photo-activation of the
U Baumann et al.
European journal of biochemistry, 152(3), 645-649 (1985-11-04)
The conformation of the anticodon loop of Escherichia coli tRNAArg was investigated. It is shown that the structure of the anticodon loop is influenced by the base composition of the anticodon stem, and the natural modification of the nucleoside residue
Akihiro Ohkubo et al.
Organic & biomolecular chemistry, 10(10), 2008-2010 (2012-01-28)
In this paper, we report DNA and 2'-OMe-RNA probes containing 5-methyl-2-thiocytidine (m(5)s(2)C) residues that can bind selectively and strongly to the corresponding RNA targets containing inosine residues by the significant stacking effect and steric hindrance of the 2-thiocarbonyl group.
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