861804
8-(Diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride
97%
Synonym(s):
TMB 8 hydrochloride, TMB-8 · HCl
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About This Item
Linear Formula:
(CH3O)3C6H2CO2(CH2)8N(C2H5)2 · HCl
CAS Number:
Molecular Weight:
431.99
EC Number:
258-574-5
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
5466611
MDL number:
assay
97%
form
powder
mp
94-97 °C (lit.)
SMILES string
Cl[H].CCN(CC)CCCCCCCCOC(=O)c1cc(OC)c(OC)c(OC)c1
InChI
1S/C22H37NO5.ClH/c1-6-23(7-2)14-12-10-8-9-11-13-15-28-22(24)18-16-19(25-3)21(27-5)20(17-18)26-4;/h16-17H,6-15H2,1-5H3;1H
InChI key
KFJZVXKPPQIYCG-UHFFFAOYSA-N
Application
- Pharmacologically active inhibitor of hepatitis C virus life cycle
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Fabián Bernal et al.
Journal of neuroscience research, 87(5), 1240-1249 (2008-11-14)
Human cerebral calcification has been related to deregulation of intracellular calcium homeostasis. In rat basal ganglia, nimodipine and TMB-8, two commonly used calcium antagonists, worsen the chronic AMPA-induced lesion, whereas only nimodipine potentiates calcification. To investigate whether similar effects are
P Fang et al.
Acta physiologica (Oxford, England), 199(1), 53-61 (2010-01-20)
The aim of this study was to determine the effects of motilin on [Ca(2+)](i) regulation and its underlying molecular mechanism in cultured antral smooth muscle cells (ASMCs). Antral cells were isolated and cultured from neonatal rats, and then the [Ca(2+)](i)
Maria A Mariggiò et al.
Peptides, 29(9), 1486-1497 (2008-06-25)
The two major isoforms (180 kDa and 140 kDa) of the neural cell adhesion molecule (N-CAM) are crucially involved in neurogenesis and brain repair via activation of the mitogen-activated protein kinase (MAPK) cascade. Modification by glycosylation, and homophilic and heterophilic
Jafar Vatanparast et al.
European journal of pharmacology, 571(2-3), 81-87 (2007-06-30)
We have previously reported that paraoxon, an organophosphate compound, at submicromolar concentrations effectively suppresses Ca2+ action potentials and modulates the activity of snail neurons. This effect was unrelated to acetylcholinesterase inhibition but was found to involve the direct or indirect
Agata Adamczyk et al.
Folia neuropathologica, 43(3), 139-142 (2005-10-26)
Our previous studies indicated that Alzheimer's disease (AD) related amyloid beta peptide (Abeta) significantly altered muscarinic cholinergic receptor (mChR) signaling on the level of G protein regulated phospholipase C (PLC) leading to the lower formation of inositol-1,4,5-triphosphate (IP3) and diacylglycerol
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