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Merck
CN

88808

(S)-(+)-1-Methoxy-2-propanol

≥98.5% (sum of enantiomers)

Synonym(s):

(S)-(+)-Propylene glycol 1-methyl ether

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About This Item

Empirical Formula (Hill Notation):
C4H10O2
CAS Number:
Molecular Weight:
90.12
UNSPSC Code:
12352112
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1718940
Assay:
≥98.5% (sum of enantiomers)
Form:
liquid
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InChI

1S/C4H10O2/c1-4(5)3-6-2/h4-5H,3H2,1-2H3/t4-/m0/s1

SMILES string

COC[C@H](C)O

InChI key

ARXJGSRGQADJSQ-BYPYZUCNSA-N

assay

≥98.5% (sum of enantiomers)

form

liquid

optical activity

[α]20/D +22±2°, c = 10% in chloroform

refractive index

n20/D 1.403

density

0.921 g/mL at 20 °C (lit.)

functional group

ether, hydroxyl

Quality Level

Application

(S)-(+)-1-Methoxy-2-propanol can be used as a reactant to prepare:
  • (S)-1-methoxypropan-2-yl 4-methylbenzenesulfonate by reacting with tosyl chloride in the presence of pyridine.
  • Thiazolopyridine urea derivatives.
  • Quinazoline derivatives as potential inhibitors of EGFR/HER-2 tyrosine kinases.

pictograms

Flame

signalword

Warning

hcodes

Hazard Classifications

Flam. Liq. 3

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

91.4 °F - closed cup

flash_point_c

33 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Discovery of new quinazoline derivatives as irreversible dual EGFR/HER2 inhibitors and their anticancer activities-Part 1
D Debasis, et al.
Bioorganic & medicinal chemistry letters, 29(4), 591-596 (2019)
Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA gyrase B
K Manoj G, et al.
Journal of Medicinal Chemistry, 56(21), 8834-8848 (2013)
Stereocontrolled C (sp 3)-P bond formation with non-activated alkyl halides and tosylates
Yang C-T, et al.
Royal Society of Chemistry Advances, 7(40), 24652-24656 (2017)

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