900210
Regenerez® Poly(glycerol sebacate) Resin
Synonym(s):
PGS, Poly(glycerol sebacic acid)
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About This Item
Linear Formula:
(C13H22O5)n
UNSPSC Code:
12352200
Application
Regenerez® Poly(glycerol sebacate) is a bioresorbable elastomer. The physical properties can be tuned from an elastomer to a thermoset(U.S. Patent No. 9.359,472) by curing PGS to the desired level of cross-linking. The inherent elastomeric properties of PGS can be used in a variety of applications in regenerative medicine and tissue engineering.
Features and Benefits
- Bioresorbable.
- Comprised of naturally occurring metabolites (glycerol and sebacic acid).
- Tunable mechanical properties.
- Versatile platform for further modification.
- Closely simulates modulus of human tissue.
- Enables healing without harmful immune response.
Legal Information
U.S. Patent No. 9,359,472.
Regenerez is a registered trademark of The Secant Group, LLC
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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Wei Wu et al.
Nature medicine, 18(7), 1148-1153 (2012-06-26)
Host remodeling is important for the success of medical implants, including vascular substitutes. Synthetic and tissue-engineered grafts have yet to show clinical effectiveness in arteries smaller than 5 mm in diameter. We designed cell-free biodegradable elastomeric grafts that degrade rapidly
Qi-Zhi Chen et al.
Journal of the mechanical behavior of biomedical materials, 4(8), 1805-1818 (2011-11-22)
Poly (glycerol sebacate) (PGS) is a promising elastomer for use in soft tissue engineering. However, it is difficult to achieve with PGS a satisfactory balance of mechanical compliance and degradation rate that meet the requirements of soft tissue engineering. In
Synthesis, properties and biomedical applications of poly(glycerol sebacate) (PGS): A review.
Rai R, et al.
Progress in Polymer Science, 37 (8), 1051-1078 (2012)
Howard I Pryor et al.
Surgery, 146(3), 490-497 (2009-09-01)
The objectives of this study were to evaluate the efficacy of poly(glycerol) sebacate (PGS) films for the prevention of visceroparietal peritoneal (VP) adhesions and demonstrate the ease of laparoscopic PGS film placement. Peritoneal adhesions occur in nearly 95% of all
Samer H Zaky et al.
Biomedical materials (Bristol, England), 9(2), 025003-025003 (2014-02-04)
For bone engineering, the optimal scaffolding material and composition has yet to be elucidated. In this study, we investigated poly (glycerol sebacate) (PGS), an elastomer known primarily for its soft tissue regeneration ability, as a suitable substrate to support osteo-precursor
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