900339
Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-maleimide
lactide:glycolide 50:50, PEG average Mn 5000, PLGA average Mn 20,000
Synonym(s):
PLGA-PEG-MAL
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About This Item
Linear Formula:
C9H11N2O3(C2H4O)x(C3H4O2)y(C2H2O2)zH
NACRES:
NA.23
UNSPSC Code:
12352200
form
chunks
Quality Level
mol wt
PEG average Mn 5000, PLGA average Mn 20,000
composition
lactide:glycolide 50:50
storage temp.
−20°C
Application
Diblock polymer can form micelles by emulsion techniques or microfluidic methods. The maleimide functional group may be used for conjugation to specific binding ligands via thiol-maleimide reaction.
Other Notes
Chapter 5: “Nanobody-Targeted and RNase-Loaded Nanoparticles Based on a Hydrophilic Polyester Aimed for Cancer Therapy” in Samadi, N.
Biodegradable Nanoparticles Based on Aliphatic Polyesters, Towards Targeted Intracellular Delivery of Protein Therapeutics. Ph.D. Thesis, Utrecht University, Utrecht, Netherlands. 2014.
Biodegradable Nanoparticles Based on Aliphatic Polyesters, Towards Targeted Intracellular Delivery of Protein Therapeutics. Ph.D. Thesis, Utrecht University, Utrecht, Netherlands. 2014.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Drug release from PLA/PEG microparticulates.
Huang YY, et al.
International Journal of Pharmaceutics, 156(1), 9-15 (1997)
LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors.
Luo G, et al.
International Journal of Pharmaceutics, 385(1-2), 150-156 (2010)