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Merck
CN

900339

Sigma-Aldrich

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-maleimide

lactide:glycolide 50:50, PEG average Mn 5000, PLGA average Mn 20,000

Synonym(s):

PLGA-PEG-MAL

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About This Item

Linear Formula:
C9H11N2O3(C2H4O)x(C3H4O2)y(C2H2O2)zH
UNSPSC Code:
12352200
NACRES:
NA.23

Key Documents

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form

chunks

Quality Level

100

mol wt

PEG average Mn 5000
PLGA average Mn 20,000

composition

lactide:glycolide 50:50

storage temp.

−20°C

Application

Diblock polymer can form micelles by emulsion techniques or microfluidic methods. The maleimide functional group may be used for conjugation to specific binding ligands via thiol-maleimide reaction.

Other Notes

Chapter 5: “Nanobody-Targeted and RNase-Loaded Nanoparticles Based on a Hydrophilic Polyester Aimed for Cancer Therapy” in Samadi, N.
Biodegradable Nanoparticles Based on Aliphatic Polyesters, Towards Targeted Intracellular Delivery of Protein Therapeutics. Ph.D. Thesis, Utrecht University, Utrecht, Netherlands. 2014.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKBZ3761

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LyP-1-conjugated nanoparticles for targeting drug delivery to lymphatic metastatic tumors.
Luo G, et al.
International Journal of Pharmaceutics, 385(1-2), 150-156 (2010)
Drug release from PLA/PEG microparticulates.
Huang YY, et al.
International Journal of Pharmaceutics, 156(1), 9-15 (1997)

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