900607
2,5-Dibromohexanediamide
≥95%
Synonym(s):
2,5-Dibromoadipamide, DBHDA
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About This Item
Empirical Formula (Hill Notation):
C6H10Br2N2O2
CAS Number:
Molecular Weight:
301.96
UNSPSC Code:
12352200
NACRES:
NA.22
MDL number:
Assay:
≥95%
Form:
solid
Quality Segment
assay
≥95%
form
solid
storage temp.
2-8°C
SMILES string
BrC(CCC(Br)C(=O)N)C(=O)N
InChI
1S/C6H10Br2N2O2/c7-3(5(9)11)1-2-4(8)6(10)12/h3-4H,1-2H2,(H2,9,11)(H2,10,12)
InChI key
PLSXNAQEJOGNKQ-UHFFFAOYSA-N
Application
This compound has been shown to be a useful reagent for the conversion of cysteine to dehydroalanine (DHA) in peptides or proteins. This enables chemical mutagenesis in which DHA can be efficiently reacted with iodide building blocks to add various natural and unnatural side chains on proteins. It was also shown that other modifications could be added through DHA such as phosphorylation, methylation, and glycosylation. In other research it was shown that DHA can be used to make ubiquitin conjugates that have a bond that mimics the native isopeptide bond.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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