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Merck
CN

900890

3-Methyl-6-propargyl-1,4-dioxane-2,5-dione

≥95%

Synonym(s):

Alkyne-functionalized lactide, Propargyl lactide

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About This Item

Empirical Formula (Hill Notation):
C8H8O4
CAS Number:
Molecular Weight:
168.15
UNSPSC Code:
12162002
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assay

≥95%

form

solid

color

white to pale yellow

storage temp.

−20°C

Application

3-Methyl-6-propargyl-1,4-dioxane-2,5-dione is a functionalized biodegradable monomer that can be polymerized using ring-opening polymerization to yield polylactide with a pendant alkyne functionality. This pendant group can be used to further functionalize the polymer or as a backbone for graft copolymer synthesis.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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″Clickable″ Polyglycolides: Tunable Synthons for Thermoresponsive, Degradable Polymers.
Jiang X, et al.
Macromolecules, 41(6), 1937-1944 (2008)
Functional Polylactide-g-Paclitaxel-Poly(ethylene glycol) by Azide-Alkyne Click Chemistry.
Yu Y, et al.
Macromolecules, 44(12), 4793-4800 (2011)
Synthesis and ring-opening polymerisation of a newalkyne-functionalised glycolide towards biocompatible amphiphilic graft copolymers.
Coumes F, et al.
Polym. Chem., 4, 3705-3713 (2013)
A degradable brush polymer-drug conjugate for pH-responsive release of doxorubicin.
Yu Y, et al.
Polym. Chem., 6, 953-961 (2015)

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