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Merck
CN

901335

Sigma-Aldrich

Polyester bis-MPA dendron

4 azide, 1 NHBoc (core), generation 2

Synonym(s):

Bis-MPA dendron, PFd-G2-BOCNH-Azide

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About This Item

Empirical Formula (Hill Notation):
C55H91N13O21
Molecular Weight:
1270.39
UNSPSC Code:
12162002

Key Documents

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form

viscous liquid

availability

available only in USA

color

colorless to faint yellow

storage temp.

−20°C

General description

  • Polymer architecture: Dendron
  • Generation: 2
  • Core functional group: Boc-protected amine
  • End group functionality: Azide
  • No. surface groups: 4
  • Calculated mol. wt.: 1270.4 g/mol
  • Boc: tert-Butyloxycarbonyl
  • Bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid.

Application

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. The azide-functionalized dendrimers can be readily functionalized using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC) or strain-promoted alkyne-azide cycloaddition (SPAAC). Additionally, the amine-functionalized core can be readily used in EDC or DCC coupling reactions (after boc deprotection) with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.

Pictograms

Flame
GHS02

Signal Word

Danger

Hazard Statements

H242

Hazard Classifications

Self-react. C

Storage Class Code

5.2 - Organic peroxides and self-reacting hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCN1390
MKCF9286

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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Articles

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

New Multi-Dendrimer Platforms for Supramolecular Assembly

Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).

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