901394
Polyester bis-MPA dendron
no. Surface Groups 16, carboxyl, 1 NHBoc (core), generation 4
Synonym(s):
PFd-G4-BOCNH-COOH, bis-MPA dendron
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About This Item
Empirical Formula (Hill Notation):
C155H215NO101
Molecular Weight:
3708.31
NACRES:
NA.23
UNSPSC Code:
12162002
form
solid
mol wt
generation 4
no. Surface Groups
16
color
white to off-white
storage temp.
−20°C
General description
Polyester bis-MPA dendron (16 carboxyl, 1 NHBoc (core), generation 4), a high generation dendron, is synthesized by using anhydride activated bis-MPA monomers via divergent growth. It has a large and exact number of reactive groups and has dual functionalization capacity that makes it useful as a high-value scaffold.
- Polymer architecture: Dendron
- Generation: 4
- Core functional group: Boc-protected amine
- End Group Functionality: Carboxylic acid
- No. Surface Groups: 16
- Calculated Mol. Wt.: 3708.33 g/mol
- Boc : tert-Butyloxycarbonyl
- bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid
Application
Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. Both the carboxylic acid-functionalized dendrimers and amine-functionalized (after Boc deprotection) core can be readily used in EDC or DCC coupling reactions with amine or carbonyl-containing compounds, respectively, to yield highly functionalized materials for a variety of biomedical applications.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.
Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).
Rapid Synthesis of Functionalized High-Generation Polyester Dendrimers via Strain-Promoted Alkyne-Azide Cycloaddition
McNelles SA and Adronov Al
Macromolecules, 50(20), 7993-8001 (2017)
Fluoride-promoted esterification (FPE) chemistry: A robust route to Bis-MPA dendrons and their postfunctionalization
Stenstrom P, et al.
Molecules (Basel), 21(3), 366-366 (2016)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 901394-100MG | 04061835504244 |