901422
Poly(N-isopropylacrylamide)
average Mn 85,000
Synonym(s):
NIPAM polymer, PNIPAM, PolyNIPAM, Polyacrylamide, polyNIPAM
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About This Item
Linear Formula:
CH3(C6H11NO)nCH3
CAS Number:
UNSPSC Code:
12162002
NACRES:
NA.23
MDL number:
form
crystals
mol wt
Mn 60,000-110,000 Da by MALLS (GPC), average Mn 85,000
color
white to off-white
mp
96 °C
storage temp.
2-8°C
SMILES string
CC(C)NC(=O)C=C
InChI
1S/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)
InChI key
WDFKEEALECCKTJ-UHFFFAOYSA-N
General description
Poly(N-isopropylacrylamide) (PNIPAM) is a temperature-responsive polymer used in biomedical research applications. PNIPAM undergoes a reversible, lower critical solution temperature (LCST) phase transition when heated above 32 °C, transitioning from a soluble to an insoluble material. PNIPAM is also frequently crosslinked to yield hydrogels with reversible, thermal shrinking and swelling. Poly(N-isopropylacrylamide) is also readily functionalized and has been used as the hydrophilic block in the synthesis of thermoresponsive, amphiphilic block copolymers. Due to the similarity in temperature between the LCST of PNIPAM and the temperature of the human body, PNIPAM materials have been frequently utilized in tissue engineering and controlled drug delivery research applications.
Application
PNIPAM can be used in the formation of a smart hydrogel, which finds potential usage in sensors, fuel cells, supercapacitors, and lithium-ion batteries. It can also be used in the fabrication of molecular nanothermometer. PNIPAM is coated with gold nanoparticles (AuNPs) to form microgels that facilitate highly reproducible signals for surface-enhanced Raman scattering (SERS).
Thermosensitive polymer, can be used to form a hydrogel. Aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to ca. 32 °C.
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
Professor Mitsuhiro Ebara provides insights on several types of smart nanofiber mesh systems that have been explored for different drug delivery purposes.
Antti Rahikkala et al.
Biomacromolecules, 16(9), 2750-2756 (2015-07-25)
Thermally responsive hydrogel nanoparticles composed of self-assembled polystyrene-b-poly(N-isopropylacrylamide)-b-polystyrene block copolymers and fluorescent probe 1-anilinonaphthalene-8-sulfonic acid have been prepared by aerosol flow reactor method. We aimed exploring the relationship of intraparticle morphologies, that were, PS spheres and gyroids embedded in PNIPAm
Nanorod-coated PNIPAM microgels: thermoresponsive optical properties
Karg M, et al.
Small, 3(7), 1222-1229 (2007)
Muhammad Abdul Haq et al.
Materials science & engineering. C, Materials for biological applications, 70(Pt 1), 842-855 (2016-10-25)
Materials which adjust their properties in response to environmental factors such as temperature, pH and ionic strength are rapidly evolving and known as smart materials. Hydrogels formed by smart polymers have various applications. Among the smart polymers, thermoresponsive polymer poly(N-isopropylacrylamide)(PNIPAM)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 901422-10G | 04061835508327 |