901609
Diisopropylcarbodiimide solution
1 M in dichloromethane
Synonym(s):
Diisopropylmethanediimine
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About This Item
form
liquid
reaction suitability
reaction type: Coupling Reactions
concentration
1 M in dichloromethane
refractive index
n/D 1.4251
density
1.2231
application(s)
peptide synthesis
InChI
1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
InChI key
BDNKZNFMNDZQMI-UHFFFAOYSA-N
General description
DIC is an abbreviated form of N,N′-diisopropylcarbodiimide. It plays a role in the cyclization of N-(β-hydroxy)amides to form 2-oxazolines.
Application
- Alternative to dicyclohexylcarbodiimide in peptide synthesis.
- Coupling reagent for peptide syntheses.
- DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.
Valuable reagent offered as a solution in dichloromethane for more convenient handling.
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signalword
Danger
Hazard Classifications
Acute Tox. 2 Inhalation - Carc. 2 - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Central nervous system
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
91.4 °F
flash_point_c
33 °C
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