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Merck
CN

901609

Diisopropylcarbodiimide solution

1 M in dichloromethane

Synonym(s):

Diisopropylmethanediimine

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About This Item

Linear Formula:
C7H14N2
CAS Number:
693-13-0
UNSPSC Code:
12352200
MDL number:
MFCD00065689

Key Documents

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InChI

1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key

BDNKZNFMNDZQMI-UHFFFAOYSA-N

form

liquid

reaction suitability

reaction type: Coupling Reactions

concentration

1 M in dichloromethane

refractive index

n/D 1.4251

density

1.2231

application(s)

peptide synthesis

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General description

DIC is an abbreviated form of N,N′-diisopropylcarbodiimide. It plays a role in the cyclization of N-(β-hydroxy)amides to form 2-oxazolines.

Application

  • Alternative to dicyclohexylcarbodiimide in peptide synthesis.
  • Coupling reagent for peptide syntheses.
  • DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.
Valuable reagent offered as a solution in dichloromethane for more convenient handling.

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Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Carc. 2 - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

91.4 °F

flash_point_c

33 °C

Regulatory Information

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Lot/Batch Number
MKCG2654

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