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Merck
CN

901609

Sigma-Aldrich

Diisopropylcarbodiimide solution

1 M in dichloromethane

Synonym(s):

Diisopropylmethanediimine

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About This Item

Linear Formula:
C7H14N2
CAS Number:
693-13-0
MDL number:
MFCD00065689
UNSPSC Code:
12352200

Key Documents

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form

liquid

reaction suitability

reaction type: Coupling Reactions

concentration

1 M in dichloromethane

refractive index

n/D 1.4251

density

1.2231

application(s)

peptide synthesis

InChI

1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key

BDNKZNFMNDZQMI-UHFFFAOYSA-N

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General description

DIC is an abbreviated form of N,N′-diisopropylcarbodiimide. It plays a role in the cyclization of N-(β-hydroxy)amides to form 2-oxazolines.

Application

  • Alternative to dicyclohexylcarbodiimide in peptide synthesis.
  • Coupling reagent for peptide syntheses.
  • DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.
Valuable reagent offered as a solution in dichloromethane for more convenient handling.

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Carc. 2 - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

91.4 °F

Flash Point(C)

33 °C

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCG2654

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Journal of the American Chemical Society, 127(22), 8008-8009 (2005-06-02)
Gold nanoparticles with a single carboxylic acid group on the surface were prepared from a solid phase place exchange reaction and then coupled to polylysine using an in situ activation agent, diisopropylcarbodiimide (DIPCDI). The covalent amide bond linkage between the
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The Journal of biological chemistry, 280(9), 7487-7492 (2004-12-30)
EmrE is a small multidrug transporter in Escherichia coli that extrudes various positively charged drugs across the plasma membrane in exchange with protons, thereby rendering cells resistant to these compounds. Biochemical experiments indicate that the basic functional unit of EmrE
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A new method has been developed to synthesize fluorescein labeled peptides, compounds of increasing importance in bioorganic chemistry, cell biology, pharmacology, drug targeting and medicinal chemistry. We show, that 4(5)-carboxyfluorescein is much more efficient than the hitherto predominantly utilized reagents
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