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Merck
CN

901756

Low endotoxin gelatin from porcine skin

gel strength 240-360 (Bloom), <10 EU/g Endotoxin

Synonym(s):

beMatrix™ gelatin LS-H

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About This Item

CAS Number:
9000-70-8
MDL number:
MFCD00564673
NACRES:
NA.23
UNSPSC Code:
41116130

Key Documents

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Product Name

Low endotoxin gelatin from porcine skin, gel strength 240-360 (Bloom), <10 EU/g Endotoxin

form

powder

impurities

<10 EU/g Endotoxin
<300 g Total viable aerobic count

loss

<15% loss on drying

color

white to pale yellow

pH

5.0-6.5

viscosity

4.0-6.5 mPa.s

anion traces

sulfite (SO32-): <1.5 mg/20g

cation traces

As: <1 ppm
Hg: <0.1 ppm
heavy metals: <20 ppm

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Application

Gelatin has received significant attention in the biomedical field due to its inherent bioactivity. Low endotoxin gelatin from porcine skin, gel strength 300 bloom is a high bloom (high molecular weight) gelatin featuring less than 10 endotoxin units (EU) per gram. Endotoxins primarily consist of lipopolysaccharides from the outer membrane of gram-negative bacteria. Once in the bloodstream, endotoxins are capable of eliciting a strong immune response, potentially leading to fever, shock, a drop in blood pressure, and even potentially death. In addition to this immune response, several reports suggest endotoxins may also damage various types of cells. To avoid adverse effects, raw materials should contain the lowest level of endotoxins possible when used in biomedical or regenerative medicine research applications. This low endotoxin gelatin is derived from alkaline-treated porcine skin and has a variety of potential applications in the fields of regenerative medicine, medical devices, and tissue engineering research.

Legal Information

beMatrix is a trademark of Nitta Gelatin

Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料
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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ8667

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T Kirikae et al.
International journal of immunopharmacology, 19(5), 255-262 (1997-05-01)
Trace amounts of endotoxin (lipopolysaccharide: LPS) are assumed to contaminate commercially available fetal bovine serum (FBS) for tissue or cell culture during the manufacturing process. We examined how cultured cells were affected by the endotoxin and how much endotoxin was
K W Brunson et al.
Journal of supramolecular structure, 9(2), 231-242 (1978-01-01)
Chinese hamster ovary (CHO . K1 . PRO) cell growth was inhibited by addition of a gram-negative bacterial lipopolysaccharide (LPS) to the cell culture medium. Growth inhibition began after three or four days of incubation, was dose-dependent up to a
J M Harlan et al.
Laboratory investigation; a journal of technical methods and pathology, 48(3), 269-274 (1983-03-01)
Lipopolysaccharide (LPS) produced time- and dose-dependent bovine endothelial cell injury in vitro that was manifested initially by cell detachment from culture substrate with subsequent cell lysis. Bovine endothelial cell injury was observed with LPS derived from Salmonella minnesota R595, a
J Ongrádi et al.
Folia microbiologica, 29(6), 450-454 (1984-01-01)
Cytotoxicity of a mixed pyrogen preparation and its components as well as native and radiodetoxified lipopolysacharides (LPS) was determined with established HEp-2 cell cultures and by measuring plating efficiency. This proved to be more sensitive to the damaging effect of
J G Brock-Utne et al.
Anaesthesia and intensive care, 17(1), 49-55 (1989-02-01)
Endotoxins (lipopolysaccharides, LPS) are potent bacterial poisons always present within the intestines in considerable amounts. Several pathophysiological conditions such as hypovolaemia, hypoxia, intestinal ischaemia, burns and radiation lead to a breakdown in the barrier and depending upon the extent of
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