901942
Pyridyl disulfide poly(ethylene glycol)-block-poly(lactide-co-glycolide)
PEG average Mn 5000, PLGA average Mn 15000, lactide:glycolide 50:50
Synonym(s):
PDS-PEG-b-PLGA, PDS-PEG-PLGA
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About This Item
Linear Formula:
C8H10S2NO(C2H4O)nC2H4O[(C2H2O2)x(C3H4O2)y]m
UNSPSC Code:
12352005
NACRES:
NA.23
description
Feed Ratio: 50:50 ± 5 (Lactide:Glycolide, by NMR)
Identity: Conforms to structure (by NMR)
form
powder
feed ratio
lactide:glycolide 50:50
mol wt
PEG Mn 4000-6000 g/mol (By NMR)
PEG average Mn 5000
PLGA Mn 13500-16500 g/mol (by NMR)
PLGA average Mn 15000
color
white
storage temp.
−20°C
Application
Pyridyl disulfide poly(ethylene glycol)-block-poly(lactide-co-glycolide) is a pyridyl disulfide (PDS)-functionalized, biocompatible, amphiphilic block copolymer. Due to its self-assembling properties, this material can be used in the formation of nanoparticles for drug delivery. Additionally, due to the PDS-functionalization of the PEG block, this material can be used to rapidly covalently conjugate biomolecules, API, or targeting ligands. Potential uses include the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anaesthetic agents.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties and nanomedical applications as drug delivery system
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Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated to specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the blood-brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high
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Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
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