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Merck
CN

901966

Cellulose-Alginate-RGD bioink

suitable for 3D bioprinting applications

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About This Item

NACRES:
NA.23
UNSPSC Code:
12352201

Key Documents

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form

liquid

impurities

<25 EU/mL Endotoxin

color

white

pH

6.5-7

density

1.050 g/mL

application(s)

3D bioprinting

storage temp.

2-8°C

General description

3D bioprinting is the printing of biocompatible materials, cells, growth factors, and the other supporting materials necessary to yield functional complex living tissues. 3D bioprinting has been used to generate several different types of tissue such as skin, bone, vascular grafts, and cartilage structures. Based upon the desired properties, different materials and formulations can be used to generate both hard and soft tissues. While several 3D printing methods exist, due to the sensitivity of the materials used, extrusion-based methods with bioinks are most commonly employed.

Material comes prepackaged in syringe with 5ml of product.

Application

Due to its low cost, biocompatibility, and facile gelation, alginate is one of the most common components of commercial bioinks. Alginate is a naturally-occurring polysaccharide, obtained from the cell walls of brown algae, that is composed of guluronic and mannuronic acid. While alginate forms hydrogels under mild conditions, nanocellulose is added in this formulation to improve printability and final structure properties. In addition to alginate and nanocellulose, Arg-Gly-Asp (RGD) motifs have been added to improve cell adhesion after printing. Cellulose-Alginate-RGD acellular bioink is provided as a ready-to-print, low endotoxin, and aseptic formulation in 5 mL syringes.

Analysis Note

Appearance: White viscous gel

Legal Information

Product of Cellink

Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCM4519
MKCH0503

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Carmen C Piras et al.
Biomaterials science, 5(10), 1988-1992 (2017-08-23)
3D bioprinting is a new developing technology with lots of promise in tissue engineering and regenerative medicine. Being biocompatible, biodegradable, renewable and cost-effective, cellulosic nanomaterials have recently captured the attention of researchers due to their applicability as inks for 3D
P Selcan Gungor-Ozkerim et al.
Biomaterials science, 6(5), 915-946 (2018-03-02)
Bioprinting is an emerging technology with various applications in making functional tissue constructs to replace injured or diseased tissues. It is a relatively new approach that provides high reproducibility and precise control over the fabricated constructs in an automated manner

Articles

Three-Dimensional Bioprinting for Tissue and Disease Modeling

Professor Shrike Zhang (Harvard Medical School, USA) discusses advances in 3D-bioprinted tissue models for in vitro drug testing, reviews bioink selections, and provides application examples of 3D bioprinting in tissue model biofabrication.

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