902691
Hydroxy-PEG5-t-butyl ester
Synonym(s):
tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu
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About This Item
Empirical Formula (Hill Notation):
C17H34O8
CAS Number:
Molecular Weight:
366.45
UNSPSC Code:
51171641
MDL number:
Assay:
≥95%
Form:
liquid
SMILES string
O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO
assay
≥95%
form
liquid
reaction suitability
reagent type: cross-linking reagent
refractive index
n/D 1.448
density
1.071
functional group
ester, hydroxyl
storage temp.
−20°C
Application
This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
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Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Jordan H Wosnick et al.
Journal of the American Chemical Society, 127(10), 3400-3405 (2005-03-10)
A set of carboxylate-functionalized poly(phenylene ethynylene)s (PPEs) has been synthesized in which the carboxylic acid groups are separated from the polymer backbone by oligo(ethylene glycol) spacer units. These polymers are soluble in water and organic solvents and have photophysical properties
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