909661
d0-DMDSSO crosslinker
≥95%
Synonym(s):
Bis(2,5-dioxopyrrolidin-1-yl) 3,3′-sulfinylbis(2-methylpropanoate), Mass spectrometry-cleavable crosslinker for studying protein-protein interactions
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About This Item
Empirical Formula (Hill Notation):
C16H20N2O9S
CAS Number:
Molecular Weight:
416.40
UNSPSC Code:
12352106
assay
≥95%
form
powder
storage temp.
2-8°C
Application
d0-DMDSSO (dimethyl-disuccinimidyl sulfoxide) crosslinker is a homobifunctional, lysine residue-targeting, sulfoxide-containing crosslinker for analysis of protein-protein interactions (PPIs) through crosslinking mass spectrometry (XL-MS). d0-DMDSSO possesses two N-hydroxysuccinimide (NHS) ester groups for targeting amines and two symmetrical C-S cleavable bonds adjacent to the central sulfoxide. The post-cleavage spacer yields tagged peptides for unambiguous identification by collision-induced dissociation in tandem MS. d0-DMDSSO crosslinker will also be a useful proteomics tool and aid in the quest for targeting ″undruggable″ protein targets.
Other Notes
Legal Information
Subject to US Patent Application #15/275,001 of the Regents of the University of California
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
Sulfoxide-containing MS-cleavable cross-linkers capture protein-protein interactions in native cellular environments, aiding PPI identification.
Clinton Yu et al.
Analytical chemistry, 86(4), 2099-2106 (2014-01-30)
Structural characterization of protein complexes is essential for the understanding of their function and regulation. However, it remains challenging due to limitations in existing tools. With recent technological improvements, cross-linking mass spectrometry (XL-MS) has become a powerful strategy to define