91862
Trimethyl(trifluoromethyl)silane solution
2 M in THF
Synonym(s):
(Trifluoromethyl)trimethylsilane, Ruppert′s reagent, Ruppert-Prakash reagent, TFMTMS, Trifluoromethyltrimethylsilane
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About This Item
InChI
1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
SMILES string
C[Si](C)(C)C(F)(F)F
InChI key
MWKJTNBSKNUMFN-UHFFFAOYSA-N
form
liquid
reaction suitability
reaction type: C-C Bond Formation
IVD
for in vitro diagnostic use
concentration
2 M in THF
refractive index
n20/D 1.386
density
0.91 g/mL at 20 °C
functional group
fluoro
Quality Level
General description
Application
- Silver-mediated C-H trifluoromethylation of arenes
- Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8
- Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts
- Palladium-catalyzed oxidative trifluoromethylation of indoles
- Preparation of 5-HT1A antagonists
- Used as difluorocarbene source
- Conversion of aromatic aldehydes to difluoromethylated products.
- C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction.
It can also be used in trifluoromethylation of:
- Non-activated aldimines.
- Heterocumulenes.
- Azomethine imines.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
target_organs
Respiratory system
supp_hazards
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
1.4 °F
flash_point_c
-17 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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