923818
N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide
Synonym(s):
Coumarin alkyne CoLDR probe
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C17H15NO4
Molecular Weight:
297.31
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.22
InChI key
MTTOLTREJYBDSH-UHFFFAOYSA-N
SMILES string
O=C1OC2=CC(OCC(C(NCCC#C)=O)=C)=CC=C2C=C1
reaction suitability
reagent type: chemical modification reagent
reaction type: click chemistry
functional group
(Alkyne)
storage temp.
2-8°C
Quality Level
Related Categories
Application
N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide is a proteomic cysteine probe. As described in Reddi et al, the Nir London lab developed a-substituted N-alkynyl-methacrylamides for covalent ligand directed release chemistry (CoLDR). CoLDR represents a new type of acrylamide-based electrophiles for targeted covalent inhibitor discovery and design. Specifically this CoLDR probe is a coumarin derivative with a terminal alkyne for click chemistry.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Rambabu N Reddi et al.
Journal of the American Chemical Society, 143(13), 4979-4992 (2021-03-26)
Targeted covalent inhibitors are an important class of drugs and chemical probes. However, relatively few electrophiles meet the criteria for successful covalent inhibitor design. Here we describe α-substituted methacrylamides as a new class of electrophiles suitable for targeted covalent inhibitors.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service