930482
Oligo(poly(ethylene glycol) fumarate)
average Mn 4,500
Synonym(s):
OPF, Oligo(PEG fumarate), PEG fumarate
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About This Item
Linear Formula:
(C2H4O)n(C4H2O3(C2H4O)n)mH2O
UNSPSC Code:
12352104
NACRES:
NA.25
General description
Oligo(poly(ethylene glycol) fumarate) (OPF) is a derivative of poly(ethylene glycol) (PEG). The unsaturated fumarate groups render it crosslinkable and biodegradable, with tunable mechanical properties. The multiple double bonds along the linear macromolecular chain allow for crosslinking in aqueous solutions in the presence of thermal, chemical or photochemical radical initiators.
Application
- Biomedical applications
- Drug delivery
- Tissue engineering
- 3D bioprinting
Features and Benefits
- Biodegradable and cytocompatible
- Crosslinkable
- Tunable mechanical properties
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Heungsoo Shin et al.
Biomacromolecules, 4(3), 552-560 (2003-05-14)
Currently, oligo[poly(ethylene glycol) fumarate] (OPF) hydrogels are being investigated as an injectable and biodegradable system for tissue engineering applications. In this study, cytotoxicity of each component of the OPF hydrogel formulation and the resulting cross-linked network was examined. Specifically, OPF
Mahrokh Dadsetan et al.
Biomacromolecules, 8(5), 1702-1709 (2007-04-11)
Photo-cross-linkable oligo[poly(ethylene glycol) fumarate] (OPF) hydrogels have been developed for use in tissue engineering applications. We demonstrated that compressive modulus of these hydrogels increased with increasing polymer concentration, and hydrogels with different mechanical properties were formed by altering the ratio
Synthesis and Characterization of Oligo(poly(ethylene glycol) fumarate) Macromer.
Seongbong J, et al.
Macromolecules, 34, 2839-2844 (2001)
Theresa A Holland et al.
Journal of controlled release : official journal of the Controlled Release Society, 101(1-3), 111-125 (2004-12-14)
This work describes the development of a non-invasive means of simultaneously delivering insulin-like growth factor-1 (IGF-1) and transforming growth factor-beta1 (TGF-beta1) to injured cartilage tissue in a controlled manner. This novel delivery technology employs the water-soluble polymer, oligo(poly(ethylene glycol) fumarate)
Xifeng Liu et al.
Journal of biomedical materials research. Part A, 109(1), 6-17 (2020-05-18)
3D bioprinting is a promising new tissue restoration technique that enables the precise deposition of cells and growth factors in order to more closely mimic the structure and function of native organs. In this study, we report the development of
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