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Merck
CN

930482

Sigma-Aldrich

Oligo(poly(ethylene glycol) fumarate)

average Mn 4,500

Synonym(s):

OPF, Oligo(PEG fumarate), PEG fumarate

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About This Item

Linear Formula:
(C2H4O)n(C4H2O3(C2H4O)n)mH2O
UNSPSC Code:
12352104
NACRES:
NA.25

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form

viscous liquid (to powder)

Quality Level

100

mol wt

average Mn 4,500

color

white

storage temp.

−20°C

Related Categories

General description

Oligo(poly(ethylene glycol) fumarate) (OPF) is a derivative of poly(ethylene glycol) (PEG). The unsaturated fumarate groups render it crosslinkable and biodegradable, with tunable mechanical properties. The multiple double bonds along the linear macromolecular chain allow for crosslinking in aqueous solutions in the presence of thermal, chemical or photochemical radical initiators.

Application

  • Biomedical applications
  • Drug delivery
  • Tissue engineering
  • 3D bioprinting

Features and Benefits

  • Biodegradable and cytocompatible
  • Crosslinkable
  • Tunable mechanical properties

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Mahrokh Dadsetan et al.
Biomacromolecules, 8(5), 1702-1709 (2007-04-11)
Photo-cross-linkable oligo[poly(ethylene glycol) fumarate] (OPF) hydrogels have been developed for use in tissue engineering applications. We demonstrated that compressive modulus of these hydrogels increased with increasing polymer concentration, and hydrogels with different mechanical properties were formed by altering the ratio
Heungsoo Shin et al.
Biomacromolecules, 4(3), 552-560 (2003-05-14)
Currently, oligo[poly(ethylene glycol) fumarate] (OPF) hydrogels are being investigated as an injectable and biodegradable system for tissue engineering applications. In this study, cytotoxicity of each component of the OPF hydrogel formulation and the resulting cross-linked network was examined. Specifically, OPF
Synthesis and Characterization of Oligo(poly(ethylene glycol) fumarate) Macromer.
Seongbong J, et al.
Macromolecules, 34, 2839-2844 (2001)
In vitro release of transforming growth factor-?1 from gelatin microparticles encapsulated in biodegradable, injectable oligo(poly(ethylene glycol) fumarate) hydrogels
Hollanda, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 91, 299-313 (2003)
Theresa A Holland et al.
Journal of controlled release : official journal of the Controlled Release Society, 101(1-3), 111-125 (2004-12-14)
This work describes the development of a non-invasive means of simultaneously delivering insulin-like growth factor-1 (IGF-1) and transforming growth factor-beta1 (TGF-beta1) to injured cartilage tissue in a controlled manner. This novel delivery technology employs the water-soluble polymer, oligo(poly(ethylene glycol) fumarate)
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