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Merck
CN

933082

Sigma-Aldrich

NanoFabTx™ NanoFlash PEG-PLA drug formulation screening kit

for CIJ synthesis of nanoparticles

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.21

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storage temp.

2-8°C

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Application

NanoFabTx™ NanoFlash PEG-PLA drug formulation screening kit is a ready to use nanoformulation kit for flash nanoprecipitation synthesis of PEGylated PLA nanoparticles for drug delivery research applications. This kit contains rationally selected PEGylated PLA polymers and stabilizer, enabling users to screen and select nanoformulations without the need for lenghty trial and error optimization. These PEGylated PLA polymers have been widely used in drug delivery systems for controlled drug release of many different types of therapeutic molecules.

This kit has been curated and designed for flash nanoprecipitiaton (FNP) nanoparticle synthesis using a confined impingement jet (CIJ) mixer, such as the NanoFabTx™ NanoFlash CIJ Mixer, and detailed step-by-step instructions are provided.

Features and Benefits

  • Ready-to-use nanoformulation kit for PEGylated nanoparticles
  • Step-by-step flash nanoprecipitation protocol
  • Create specifically sized, biodegradable, PEGylated PLA nanoparticles
  • Maximize the encapsulation of hydrophobic drugs
  • Two different PEGylated PLAs are included
  • Optimized for 60 nm-150 nm nanoparticles
A flash nanoprecipitation protocol to prepare drug-encapsulated nanoparticles using the NanoFabTx™ NanoFlash CIJ Mixer is included and can be found under the Protocol section of this page.

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Jing Han et al.
Journal of pharmaceutical sciences, 101(10), 4018-4023 (2012-07-11)
Johnson and Prud'homme (2003. AICHE J 49:2264-2282) introduced the confined impingement jets (CIJ) mixer to prepare nanoparticles loaded with hydrophobic compounds (e.g., drugs, inks, fragrances, or pheromones) via flash nanoprecipitation (FNP). We have modified the original CIJ design to allow
C Thomasin et al.
Journal of pharmaceutical sciences, 87(3), 269-275 (1998-04-02)
Phase separation (frequently called coacervation) of poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) is a classical method for drug microencapsulation. Here, attempts have been made to describe this process in the light of thermodynamics. Different PLA/PLGAs were dissolved in either dichloromethane or
Robert F Pagels et al.
Journal of controlled release : official journal of the Controlled Release Society, 219, 519-535 (2015-09-12)
Biologically derived therapeutics, or biologics, are the most rapidly growing segment of the pharmaceutical marketplace. However, there are still unmet needs in improving the delivery of biologics. Injectable polymeric nanoparticles and microparticles capable of releasing proteins and peptides over time
Nazila Kamaly et al.
Chemical Society reviews, 41(7), 2971-3010 (2012-03-06)
Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years. These materials have evolved from their earlier use as biodegradable products such as resorbable sutures, orthopaedic implants, macroscale and microscale drug delivery
Verónica Lassalle et al.
Macromolecular bioscience, 7(6), 767-783 (2007-06-02)
The controlled release of medicaments remains the most convenient way of drug delivery. Therefore, a wide variety of reports can be found in the open literature dealing with drug delivery systems. In particular, the use of nano- and microparticles devices
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