Skip to Content
Merck
CN

938319

Sigma-Aldrich

Dibromopyridazinedione-BCN

Synonym(s):

((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methyl (2-(2-(2-(3-(4,5-dibromo-2-methyl-3,6-dioxo-3,6-dihydropyridazin-1(2H)-yl)propanamido)ethoxy)ethoxy)ethyl)carbamate, 5,8-Dioxa-2,11-diazatetradecanoic acid, 14-(4,5-dibromo-3,6-dihydro-2-methyl-3,6-dioxo-1(2H)-pyridazinyl)-12-oxo-, (1R,8S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester, rel-, rel-(1R,8S)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl 14-(4,5-dibromo-3,6-dihydro-2-methyl-3,6-dioxo-1(2H)-pyridazinyl)-12-oxo-5,8-dioxa-2,11-diazatetradecanoate

Sign Into View Organizational & Contract Pricing

Select a Size

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

form

liquid

Quality Level

100

storage temp.

−20°C

SMILES string

O=C(OC[C@H]1[C@@]2([H])CCC#CCC[C@@]12[H])NCCOCCOCCNC(CCN(N3C)C(C(Br)=C(Br)C3=O)=O)=O

InChI

1S/C25H34Br2N4O7/c1-30-23(33)21(26)22(27)24(34)31(30)11-8-20(32)28-9-12-36-14-15-37-13-10-29-25(35)38-16-19-17-6-4-2-3-5-7-18(17)19/h17-19H,4-16H2,1H3,(H,28,32)(H,29,35)/t17-,18+,19-

InChI key

QCFHFXWJAQSSKW-REPLKXPHSA-N

Application

New reagent for disulfide bridging, useful for ADC & Bioconjugation

Other Notes

Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4.

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000314551
0000314551

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers
Wall A, et al.
Organic & Biomolecular Chemistry, 17(34), 7870-7873 (2019)
Anders Dinesen et al.
Bioconjugate chemistry, 33(2), 333-342 (2022-02-08)
Albumin-nucleic acid biomolecular drug designs offer modular multifunctionalization and extended circulatory half-life. However, stability issues associated with conventional DNA nucleotides and maleimide bioconjugation chemistries limit the clinical potential. This work aims to improve the stability of this thiol conjugation and

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service