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Merck
CN

938319

Dibromopyridazinedione-BCN

Synonym(s):

((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)methyl (2-(2-(2-(3-(4,5-dibromo-2-methyl-3,6-dioxo-3,6-dihydropyridazin-1(2H)-yl)propanamido)ethoxy)ethoxy)ethyl)carbamate, 5,8-Dioxa-2,11-diazatetradecanoic acid, 14-(4,5-dibromo-3,6-dihydro-2-methyl-3,6-dioxo-1(2H)-pyridazinyl)-12-oxo-, (1R,8S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester, rel-, rel-(1R,8S)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl 14-(4,5-dibromo-3,6-dihydro-2-methyl-3,6-dioxo-1(2H)-pyridazinyl)-12-oxo-5,8-dioxa-2,11-diazatetradecanoate

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About This Item

Empirical Formula (Hill Notation):
C25H34Br2N4O7
CAS Number:
2416301-36-3
Molecular Weight:
662.37
NACRES:
NA.21
Form:
liquid

Key Documents

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SMILES string

O=C(OC[C@H]1[C@@]2([H])CCC#CCC[C@@]12[H])NCCOCCOCCNC(CCN(N3C)C(C(Br)=C(Br)C3=O)=O)=O

InChI key

QCFHFXWJAQSSKW-REPLKXPHSA-N

InChI

1S/C25H34Br2N4O7/c1-30-23(33)21(26)22(27)24(34)31(30)11-8-20(32)28-9-12-36-14-15-37-13-10-29-25(35)38-16-19-17-6-4-2-3-5-7-18(17)19/h17-19H,4-16H2,1H3,(H,28,32)(H,29,35)/t17-,18+,19-

form

liquid

storage temp.

−20°C

Quality Level

100

Application

New reagent for disulfide bridging, useful for ADC & Bioconjugation

Other Notes

Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000314551
0000314551

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Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers
Wall A, et al.
Organic & Biomolecular Chemistry, 17(34), 7870-7873 (2019)
Anders Dinesen et al.
Bioconjugate chemistry, 33(2), 333-342 (2022-02-08)
Albumin-nucleic acid biomolecular drug designs offer modular multifunctionalization and extended circulatory half-life. However, stability issues associated with conventional DNA nucleotides and maleimide bioconjugation chemistries limit the clinical potential. This work aims to improve the stability of this thiol conjugation and

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