939870
Folic acid modified polyethylenimine solution
low molecular weight, 10 mg/mL (aqueous solution), suitable for biomedical research
Synonym(s):
PEI-Folate
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About This Item
Linear Formula:
N2CH2H2R2(C23H53R4N11)n
UNSPSC Code:
12352200
Quality Level
form
liquid
concentration
10 mg/mL (aqueous solution)
color
faint yellow to yellow
solubility
soluble, clear to hazy
storage temp.
2-8°C
SMILES string
[R]NCCN(CCN[R])CCNCCN(CCNCCN[R])CCN(CCN(CCN[R])CCN[R])CCNCCN[R].NC1=NC(C(N=C(CNC2=CC=C(C(N[C@@H](CCC(C)=O)C(O)=O)=O)C=C2)C=N3)=C3N1)=O.CC
General description
The low weight folic acid modified polyethylenimine (PEI) solution is a versatile cationic polymer used in targeted gene delivery. Polyethylenimine (PEI) is one of the most attractive and widely studied gene delivery systems both in vitro and in vivo due to its high transfection efficiency in a broad range of cells. Folic acid or folate (FA) has emerged as an ideal targeting ligand, prized for its compact size, low immunogenicity, low toxicity and strong affinity to the folate receptor. Through the folic acid modification of polyethylenimine, this solution blends the advantages of both to maximize transfection efficiency and enable targeted drug and gene delivery while maintaining low toxicity.
Application
This folic acid modified branched PEI solution has garnered significant attention in the field of gene transfection and drug delivery research. Some applications include:
- Cancer treatment - Folate receptors (FRs) are frequently overexpressed in a wide range of tumors and are rarely expressed in normal tissues. Thus, folic acid modified PEI can be used to carry anticancer drugs or gene therapies directly to the tumor site for localized and targeted delivery.
- Cancer imaging- Due to the targetability of the folic acid to tumor cells, this modified PEI can also be used for cancer imaging, aiding in early diagnosis and monitoring.
- Gene delivery - This cationic polymer plays a crucial role in non-viral gene delivery by forming stable complexes to protect the DNA or RNA during transport and enhance cellular uptake through endosomal escape.
- Small molecule delivery - PEI improves water solubility and stability of hydrophobic drugs, improving delivery and enabling controlled drug release.
Features and Benefits
- Low molecular weight branched PEI for improved water solubility and transfection efficiency
- Folic acid functionalization for targeted delivery
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Yujuan Zhang et al.
Technology and health care : official journal of the European Society for Engineering and Medicine, 24 Suppl 1, S415-S420 (2015-11-19)
RNA interference (RNAi) employs double-stranded RNA or siRNA (small interfering RNA) to silence gene expression in cells. The widespread use of RNAi therapeutics requires the development of clinically suitable, safe and effective delivery vehicles. PEI (Poly(ethylene imine)) carrying the positive
Chaoyu Liu et al.
Molecular biotechnology, 63(1), 63-79 (2020-11-04)
Polymeric vectors are safer alternatives for gene delivery owing to their advantages as compared to viral vectors. To improve the stability and transfection efficiency of poly(lactic-co-glycolic acid) (PLGA)- and poly(ethylenimine) (PEI)-based vectors, poly(ethylene glycol) (PEG), folic acid (FA), arginylglycylaspartic acid
Xiaoxiao Sun et al.
Pharmaceutics, 11(9), 430-430 (2019-08-28)
Nano anti-cancer drug carriers loaded with antineoplastic drugs can achieve targeted drug delivery, which enriches drugs at tumor sites and reduces the toxic side effects in normal tissues. Mesoporous silica nanoparticles (MSN) are good nano drug carriers, as they have
Kunn Hadinoto et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 85(3 Pt A), 427-443 (2013-07-23)
Lipid-polymer hybrid nanoparticles (LPNs) are core-shell nanoparticle structures comprising polymer cores and lipid/lipid-PEG shells, which exhibit complementary characteristics of both polymeric nanoparticles and liposomes, particularly in terms of their physical stability and biocompatibility. Significantly, the LPNs have recently been demonstrated
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