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Merck
CN

943479

7-(Diethylamino)-4-(hydroxymethyl)coumarin

new

≥95%

Synonym(s):

2H-1-Benzopyran-2-one, 7-(diethylamino)-4-(hydroxymethyl)-; 7-(Diethylamino)-4-(hydroxymethyl)-2H-1-benzopyran-2-one; 7-(Diethylamino)-4-(hydroxymethyl)-2H-chromen-2-one; 7-(Diethylamino)-4-(hydroxymethyl)-2H-chromene-2-one

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Quality Level

100

Assay

≥95%

form

amorphous solid

color

off-white to gray-brown

functional group

(hydroxymethyl substitution at the 4-position and a diethylamino group at the 7-position)

storage temp.

2-8°C

SMILES string

O=C1OC=2C=C(C=CC2C(=C1)CO)N(CC)CC

InChI

InChI=1S/C14H17NO3/c1-3-15(4-2)11-5-6-12-10(9-16)7-14(17)18-13(12)8-11/h5-8,16H,3-4,9H2,1-2H3

InChI key

NMZSXNOCNJMJQT-UHFFFAOYSA-N

General description

7-(Diethylamino)-4-(hydroxymethyl)coumarin, commonly abbreviated DEACM, is a coumarin-based fluorescent compound widely used as a photoremovable protecting group (PPG) and fluorescent probe. It belongs to the class of coumarin derivatives, featuring a hydroxymethyl substitution at the 4-position and a diethylamino group at the 7-position, giving it strong photophysical properties.

Application

A coumarin derivative useful for generation of photocontrolled PROTACs(photoPROTACs) that can cause on demand degradation using 365nm light.

Features and Benefits

DEACM absorbs light in the near-UV to blue region (~365 nm) and exhibits bright fluorescence, making it especially valuable for photo-controlled release applications (“caging” techniques), biological imaging, and fluorescent sensing. Because of its excellent quantum yield and chemical stability, DEACM is widely adopted in fields such as chemical biology, pharmaceutical R&D, photochemistry, and analytical sciences.

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000502549
0000502549

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