Skip to Content
Merck
CN

943541

AP1867-2-(carboxymethoxy)

≥95%

Synonym(s):

(1R)-1-[2-(Carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate, 2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[2-(carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)-

Sign In to View Organizational & Contract Pricing.

Select a Size

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

SMILES string

O=C(O)COC=1C=CC=CC1C(OC(=O)C2N(C(=O)C(C3=CC(OC)=C(OC)C(OC)=C3)CC)CCCC2)CCC4=CC=C(OC)C(OC)=C4

InChI key

UYXSZUBFOQLRNQ-BTIIJPOSSA-N

InChI

1S/C38H47NO11/c1-7-26(25-21-33(46-4)36(48-6)34(22-25)47-5)37(42)39-19-11-10-13-28(39)38(43)50-30(27-12-8-9-14-29(27)49-23-35(40)41)17-15-24-16-18-31(44-2)32(20-24)45-3/h8-9,12,14,16,18,20-22,26,28,30H,7,10-11,13,15,17,19,23H2,1-6H3,(H,40,41)/t26-,28-,30+/m0/s1

assay

≥95%

form

crystalline powder

reaction suitability

reaction type: Amidations, reaction type: Esterifications

storage condition

protect from light

color

white to beige

storage temp.

−20°C

Quality Level

100

General description

Ortho AP1867 is a selective binding ligand for the single point mutant FKBP12 F36V, designed with an ortho-position carboxymethoxy modification (hence “ortho”) to provide an ‘exit vector’ for downstream chemical conjugation. It is primarily used as a precursor in the dTAG™ (degradation tag) system, enabling controlled degradation of tagged proteins by recruiting the E3 ligase complex when coupled with a matching ligand.

Application

  • dTAG system / targeted protein degradation: Used as the binding ligand component in bifunctional degraders (PROTAC-type molecules) that recruit FKBP12 F36V-tagged proteins for proteasomal degradation.
  • Chemical biology tool: As a modular building block for constructing degrader molecules, chemical probes, and studying protein knockdown dynamics.
  • Drug discovery & functional genomics: Useful for validation of disease targets via induced degradation of tagged proteins.

Features and Benefits

  • High affinity ligand for FKBP12 F36V: Enables selective binding to the engineered FKBP12 mutant, which is central to the dTAG system for induced degradation.
  • Functionalised with a carboxylic acid ‘exit vector’: The ortho position acid allows further chemical derivatisation (e.g., coupling to warheads/linkers) without interfering with the ligand binding region.

Legal Information

Tough-Tags is a trademark of Diversified Biotech

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000522990
0000522990

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service