945730
Tyramine functionalized gelatin
40% functionalized
Synonym(s):
Fish gelatin, Gelatin tyramine
SMILES string
[*]NC(C)C(NCC(N1CCCC1C(NC(CCCCNC(CCC2=CC=C(O)C=C2)=O)C(NCC(NC(CCC([O-])=O)C(N3C(C(N[*])=O)CC(O)C3)=O)=O)=O)=O)=O)=O
biological source
fish
form
powder or chunks (or fibers)
Quality Level
color
white to faint yellow-brown
application(s)
3D bioprinting
tissue engineering
(Hydrogels)
storage temp.
−20°C
Related Categories
General description
Tyramine functionalized gelatin has garnered significant attention in biomedical applications due to its unique properties that enhance biocompatibility and bioactivity. Gelatin, a natural polymer derived from collagen, possesses excellent biocompatibility, biodegradability, and low immunogenicity, making it a suitable scaffold material for tissue engineering. The introduction of tyramine groups into gelatin enhances its functionality by allowing for improved cross-linking and interaction with biological molecules. This modification facilitates the development of hydrogels that can mimic the extracellular matrix, providing a supportive environment for cell adhesion, proliferation, and differentiation.
Application
The versatility of the tyramine functionalized gelatin positions it as a promising material for advancing biomedical technologies including:
- Drug delivery systems - Tyramine functionalized gelatin can be utilized to create responsive carriers that release therapeutic agents in a controlled manner. The presence of tyramine enables the formation of covalent bonds with various drugs, enhancing their stability and release profiles.
- Regenerative medicine - Tyramine modified gelatin can be tailored to respond to specific stimuli such as pH or temperature changes, allowing for targeted delivery in various biomedical applications including regenerative medicine and tissue engineering.
Features and Benefits
- Biocompatible and biodegradable
- Tyramine functionalized for improved crosslinking
- Mimics native extracellular environment to improve and support cell-matrix interactions
Regulatory Information
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