946001
3-(Maleimido)propionic acid-NHS ester
≥95%
Synonym(s):
N-Succinimidyl 3-(N-maleimido)propionate, BMPS
InChI
InChI=1S/C11H10N2O6/c14-7-1-2-8(15)12(7)6-5-11(18)19-13-9(16)3-4-10(13)17/h1-2H,3-6H2
SMILES string
O=C1C=CC(=O)N1CCC(=O)ON2C(=O)CCC2=O
assay
≥95%
form
solid
color
white to beige
storage temp.
2-8°C
Quality Level
General description
3-Maleimidopropionic Acid NHS Ester is a bifunctional crosslinker for efficient bioconjugation. The NHS ester reacts with primary amines, while the maleimide group selectively binds thiols, forming stable thioether bonds. Ideal for protein labeling, antibody-drug conjugates (ADCs), and targeted biomolecule modification. High reactivity and specificity ensure reliable results in proteomics, drug delivery, and molecular imaging.
Application
The maleimide-thiol chemistry of 3-Maleimidopropionic acid NHS ester is pivotal in ADC development, enabling precise conjugation of cytotoxic drugs to monoclonal antibodies. Its high specificity ensures selective binding to cysteine residues, while the stability of the resulting thioether bonds enhances drug delivery efficiency to target cancer cells, reducing off-target toxicity. 3-Maleimidopropionic acid NHS offers high reactivity and selectivity, reducing off-target interactions and ensuring efficient conjugation. It is widely used in proteomics and biomolecular research for precise protein labeling, and its unique properties make it a trusted choice for pharmaceutical and biotechnology applications. ,
Regulatory Information
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