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Merck
CN

96895

Z-Lys-ONp hydrochloride

≥98.0% (AT)

Synonym(s):

Nα-Z-L-lysine 4-nitrophenyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C20H23N3O6 · HCl
CAS Number:
2179-15-9
Molecular Weight:
437.87
UNSPSC Code:
12352200
NACRES:
NA.22
PubChem Substance ID:
57653793
EC Number:
218-546-5
Beilstein/REAXYS Number:
7191805
MDL number:
MFCD00039055

Key Documents

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InChI key

JFZLPXVXTZKFDV-FERBBOLQSA-N

InChI

1S/C20H23N3O6.ClH/c21-13-5-4-8-18(22-20(25)28-14-15-6-2-1-3-7-15)19(24)29-17-11-9-16(10-12-17)23(26)27;/h1-3,6-7,9-12,18H,4-5,8,13-14,21H2,(H,22,25);1H/t18-;/m0./s1

SMILES string

Cl.NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Oc2ccc(cc2)[N+]([O-])=O

assay

≥98.0% (AT)

form

powder

optical activity

[α]20/D −24±1°, c = 1% in DMF

mp

146-152 °C

application(s)

peptide synthesis

storage temp.

−20°C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBD9626V
1370163
1325041
1259387
1068283

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Srinath Kasturi Rangan et al.
Biochemistry, 42(48), 14328-14334 (2003-12-03)
Deposition of beta-amyloid (Abeta) is considered an important early event in the pathogenesis of Alzheimer's disease (AD). Clearance of Abeta thus represents a potential therapeutic approach. Antibody-mediated clearance of Abeta by vaccination inhibited and cleared Abeta deposition in animal models;
R B Aĭsina et al.
Bioorganicheskaia khimiia, 20(2), 182-189 (1994-02-01)
The effect of L-lysine on some reactions catalysed by plasmin and the plasmin-streptokinase activator complex has been studied. The constants for competitive inhibition by L-lysine of the benzyloxycarbonyl-L-lysine p-nitrophenyl ester hydrolysis by the activator (Ki 116 mM), of the plasminogen
P Ascenzi et al.
Biochimica et biophysica acta, 871(3), 319-323 (1986-06-23)
Values of steady-state and pre-steady-state parameters for the bovine alpha-thrombin-catalyzed hydrolysis of ZArgONp and ZLysONp have been determined between pH 2.5 and 8 (I = 0.1 M) at 21 +/- 0.5 degree C. Kinetic properties of bovine alpha-thrombin have been
P Ascenzi et al.
Biochimica et biophysica acta, 829(3), 415-423 (1985-07-01)
Kinetics for the hydrolysis of p-nitrophenyl esters of N-alpha-carbobenzoxy-L-amino acids catalyzed by Ancrod were determined between pH 5 and 10 (I = 0.1 M) at 21 +/- 0.5 degrees C; the results are consistent with the minimum three-step mechanism: (formula:
P Ascenzi et al.
Biochimica et biophysica acta, 871(2), 225-228 (1986-06-05)
Values of steady-state and pre-steady-state parameters for the hydrolysis of ZArgONp and ZLysONp catalysed by ancrod, the coagulating serine proteinase from the Malayan pit viper (Agkistrodon rhodostoma) venom, have been determined, between pH 2.5 and 8 (I = 0.1 M)
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