C8601
Z-Pro-OH
99%
Synonym(s):
Z-L-Proline
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About This Item
Empirical Formula (Hill Notation):
C13H15NO4
CAS Number:
Molecular Weight:
249.26
NACRES:
NA.22
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
214-557-4
MDL number:
Beilstein/REAXYS Number:
88579
Quality Level
assay
99%
form
powder or crystals
optical activity
[α]20/D −42°, c = 2 in ethanol
reaction suitability
reaction type: solution phase peptide synthesis
technique(s)
NMR: suitable
color
white
mp
76-78 °C (lit.)
application(s)
peptide synthesis
SMILES string
OC(=O)[C@@H]1CCCN1C(=O)OCc2ccccc2
InChI
1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m0/s1
InChI key
JXGVXCZADZNAMJ-NSHDSACASA-N
Application
Z-Pro-OH can be used:
- As a starting material to prepare aib-pro endothiopeptides of pharmacological importance.
- To prepare biologically significant fluorophore-labeled peptide tetramers or dimers.
- As a reactant to synthesize benzoxazole derived human neutrophil elastase (HNE) inhibitors.
ppe
Eyeshields, Gloves, type N95 (US)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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A new dendrimer scaffold for preparing dimers or tetramers of biologically active molecules
Raju N, et al.
Tetrahedron Letters, 46(9), 1463-1465 (2005)
Design and synthesis of peptide-based carboxylic acid-containing transition-state inhibitors of human neutrophil elastase
Sato F, et al.
Bioorganic & medicinal chemistry letters, 12(4), 551-555 (2002)
Cytotoxicity of carbobenzoxy-protected amino acids.
M Dolenga et al.
In vitro cellular & developmental biology : journal of the Tissue Culture Association, 28A(5), 300-302 (1992-05-01)
The `azirine/oxazolone approach?to the synthesis of Aib-Pro endothiopeptides
Budzowski A, et al.
Helvetica Chimica Acta, 91(8), 1471-1488 (2008)
Sachin Mittal et al.
Pharmaceutical research, 24(7), 1290-1298 (2007-03-23)
To determine the bioactivation and uptake of prolidase-targeted proline prodrugs of melphalan in six cancer cell lines with variable prolidase expression and to evaluate prolidase-dependence of prodrug cytotoxicity in the cell lines compared to that of the parent drug, melphalan.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C8601-10G | 04061833522585 |
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