A47052
6-Aminochrysene
95%
Synonym(s):
6-Chrysenamine
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About This Item
Empirical Formula (Hill Notation):
C18H13N
CAS Number:
Molecular Weight:
243.30
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Quality Level
Assay
95%
form
solid
mp
209-211 °C (lit.)
SMILES string
Nc1cc2c3ccccc3ccc2c4ccccc14
InChI
1S/C18H13N/c19-18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11H,19H2
InChI key
KIVUHCNVDWYUNP-UHFFFAOYSA-N
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Related Categories
Application
Produces tumors in mice.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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H Yamazaki et al.
Carcinogenesis, 14(7), 1271-1278 (1993-07-01)
We reported previously that the potent mutagen 6-aminochrysene is catalyzed principally by rat liver microsomal P4501A and P4502B enzymes to reactive metabolites that induce umu gene expression in O-acetyltransferase-over-expressing strain Salmonella typhimurium NM2009; the proposal was made that there are
R A Lubet et al.
Mutation research, 212(2), 275-284 (1989-06-01)
6-Aminochrysene and 2-aminoanthracene were activated to metabolites which were mutagenic to Salmonella typhimurium TA98 by hepatocytes or hepatic 9000 X g supernatants (S9s) from control or xenobiotic-treated rats. Hepatocytes from Aroclor-1254-treated rats were more efficient than hepatocytes from untreated rats
S Lahmy et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 35(2), 197-201 (1987-02-01)
The purpose of this study was to determine if dibenzo(c,h)acridine could be used as a probe for the N-heterocyclic aromatic compound detoxification system. The determination was achieved by cell population studies (histograms) using microspectrofluorimetry on single living cells. The results
Carcinogenicity of 6-aminochrysene in mice.
G Lambelin et al.
European journal of cancer, 11(5), 327-334 (1975-05-01)
F K Friedman et al.
Pharmacology, 31(4), 194-202 (1985-01-01)
The microsomal cytochrome P-450-dependent aryl hydrocarbon hydroxylase is important in the detoxification of polycyclic hydrocarbons as well as their activation to cytotoxic or carcinogenic derivatives. We have studied compounds that can modify the activity of this enzyme system. Three types
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