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Merck
CN

A70607

2-Amino-5-nitrophenol

technical grade, 90%

Synonym(s):

2-Hydroxy-4-nitroaniline, 3-Hydroxy-4-aminonitrobenzene, 3-Nitro-6-aminophenol, 5-Nitro-2-amino-1-hydroxybenzene, 5-Nitro-2-aminophenol, NSC 7087

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About This Item

Linear Formula:
H2NC6H3(NO2)OH
CAS Number:
Molecular Weight:
154.12
EC Number:
204-503-8
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
972974
MDL number:
Assay:
90%
Form:
crystals
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grade

technical grade

assay

90%

form

crystals

mp

198-202 °C (dec.) (lit.)

SMILES string

Nc1ccc(cc1O)[N+]([O-])=O

InChI

1S/C6H6N2O3/c7-5-2-1-4(8(10)11)3-6(5)9/h1-3,9H,7H2

InChI key

DOPJTDJKZNWLRB-UHFFFAOYSA-N

Application

Reactant for:
  • Diazotation and coupling reactions
  • Preparation of biologically and pharmacologically active molecules


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Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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2-Amino-5-nitrophenol.
IARC monographs on the evaluation of carcinogenic risks to humans, 57, 177-184 (1993-01-01)
F Chen et al.
Cancer letters, 126(1), 67-74 (1998-05-01)
Two hair dye components, carcinogenic 4-nitro-2-aminophenol and 5-nitro-2-aminophenol, induced Cu(II)-dependent DNA cleavage frequently at thymine and guanine residues in DNA fragments obtained from the c-Ha-ras-1 protooncogene. When the p53 tumor suppressor gene was used, 4-nitro-2-aminophenol caused Cu(II)-dependent piperidine-labile sites at
Weixia Zhu et al.
Se pu = Chinese journal of chromatography, 30(9), 870-875 (2013-01-05)
An analytical method was developed for the simultaneous determination of 11 aminophenols in direct and oxidized hair dyes by high performance liquid chromatography (HPLC). The samples were extracted with methanol using sodium bisulfite for anti-oxidation. The purification was carried out