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A76958

Aminopyrazine

Name: Aminopyrazine
Brand: ALDRICH

98%

Synonym(s):

Pyrazinamine

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About This Item

Empirical Formula (Hill Notation):

C₄H₅N₃

CAS Number:

5049-61-6

Molecular Weight:

95.10

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24891268

EC Number:

225-748-7

Beilstein/REAXYS Number:

107025

MDL number:

MFCD00006137

Assay:

98%

Form:

crystals

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Properties

Quality Level

200

assay

98%

form

crystals

mp

118-120 °C (lit.)

SMILES string

Nc1cnccn1

InChI

1S/C4H5N3/c5-4-3-6-1-2-7-4/h1-3H,(H2,5,7)

InChI key

XFTQRUTUGRCSGO-UHFFFAOYSA-N

Description

Application

Substrate in a four-component synthesis of imidazolidines.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Synthetic Communications, 37, 247-247 (2007)

Synthesis of some new anils: part 1. Reaction of 2-hydroxy-benzaldehyde and 2-hydroxynaphthaldehyde with 2-aminopyridene and 2-aminopyrazine.

Abdullah M Asiri et al.

Molecules (Basel, Switzerland), 12(8), 1796-1804 (2007-10-26)

New Schiff bases derived from 2-aminopyridene and 2-aminopyrazine have been synthesized. The UV-Visible spectra of the compounds have been investigated in acetonitrile and toluene. The compounds were in tautomeric equilibrium (enol-imine O- H...N, keto-amine O...H-N forms) in polar and nonpolar

Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia.

Anna Eriksson et al.

Biochemical pharmacology, 80(10), 1507-1516 (2010-08-14)

Aberrant signal transduction by mutant or overexpressed protein kinases has emerged as a promising target for treatment of acute myeloid leukemia (AML). We here present a novel low molecular weight kinase inhibitor, AKN-032, targeting the FMS-like tyrosine kinase 3 (FLT3)

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Global Trade Item Number

SKU	GTIN
A76958-50G	04061833386149
A76958-10G	04061833386125