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A78608

2-Aminopyrimidine

Name: 2-Aminopyrimidine
Brand: ALDRICH

97%

Synonym(s):

2-Pyrimidinamine

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About This Item

Empirical Formula (Hill Notation):

C₄H₅N₃

CAS Number:

109-12-6

Molecular Weight:

95.10

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24891286

EC Number:

203-648-4

Beilstein/REAXYS Number:

107014

MDL number:

MFCD00006089

Assay:

97%

Form:

powder

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Properties

Quality Level

100

assay

97%

form

powder

mp

122-126 °C (lit.)

SMILES string

Nc1ncccn1

InChI

1S/C4H5N3/c5-4-6-2-1-3-7-4/h1-3H,(H2,5,6,7)

InChI key

LJXQPZWIHJMPQQ-UHFFFAOYSA-N

Description

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.

Kamaljit Singh et al.

European journal of medicinal chemistry, 52, 82-97 (2012-03-31)

2-Aminopyrimidine based 4-aminoquinolines were synthesized using an efficacious protocol. Some of the compounds showed in vitro anti-plasmodial activity against drug-sensitive CQ(S) (3D7) and drug-resistant CQ(R) (K1) strains of Plasmodium falciparum in the nM range. In particular, 5-isopropyloxycarbonyl-6-methyl-4-(2-nitrophenyl)-2-[(7-chloroquinolin-4-ylamino)butylamino] pyrimidine depicted the lowest

One-pot microwave-assisted protocol for the synthesis of substituted 2-amino-1H-imidazoles.

D S Ermolat'ev et al.

Molecular diversity, 15(2), 491-496 (2010-08-27)

An efficient microwave-assisted one-pot two-step protocol was developed for the construction of disubstituted 2-amino-1H-imidazoles. This process involves the sequential formation of 2,3-dihydro-2-hydroxyimidazo[1,2-a]pyrimidinium salts from readily available 2-aminopyrimidines and α-bromoketones, followed by cleavage of the pyrimidine ring with hydrazine.

Using glucaminium-based ionic liquids for improving the separation of 2-aminopyrimidine-5-ylboronic acid and its pinacol ester by high performance liquid chromatography.

Manishkumar D Joshi et al.

Journal of chromatography. A, 1308, 161-165 (2013-08-21)

A reversed-phase high performance liquid chromatography (HPLC) method is described for the determination of boronic acids that are commonly present as impurities in pinacolboronate ester reagents. Boronic acids and their pinacolboronate esters are key reagents in the Suzuki-Miyaura coupling reaction.

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Global Trade Item Number

SKU	GTIN
A78608-500G	04061833386545
A78608-100G	04061833386538