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A88476

4-Methoxybenzoyl chloride

Name: 4-Methoxybenzoyl chloride
Brand: ALDRICH

99%

Synonym(s):

4-Anisoyl chloride, p-Anisoyl chloride

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About This Item

Linear Formula:

CH₃OC₆H₄COCl

CAS Number:

100-07-2

Molecular Weight:

170.59

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24891375

EC Number:

202-816-4

Beilstein/REAXYS Number:

471918

MDL number:

MFCD00000687

Assay:

99%

Form:

liquid

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Properties

Quality Segment

200

assay

99%

form

liquid

refractive index

n20/D 1.581 (lit.)

bp

262-263 °C (lit.)

mp

22 °C (lit.)

density

1.260 g/mL at 20 °C (lit.)

functional group

acyl chloride

SMILES string

COc1ccc(cc1)C(Cl)=O

InChI

1S/C8H7ClO2/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3

InChI key

MXMOTZIXVICDSD-UHFFFAOYSA-N

Description

General description

4-Methoxybenzoyl chloride is one of the reactive acylating agents that can react with carboxylic acids, alcohols and amines to yield respective carboxylic anhydrides, esters and amides.

4-methoxybenzoyl chloride reacts with potassium thiocyanate to yield isothiocyanate derivative via nucleophilic addition-elimination mechanism.

Application

4-Methoxybenzoyl chloride can be used as radical precursor in visible-light photocatalysis to synthesize various heterocyclic compounds.
It can be used to synthesize acylphosphine ligands for the rhodium-catalyzed hydrosilylation of alkenes.
Incorporation of 4-methoxybenzoyl chloride modified indium tin oxide (ITO) as cathode for the fabrication of organic light-emitting diodes (OLEDs) has been reported.
1,3 diketones synthesized from 4-methoxybenzoyl chloride can be used in one pot synthesis of various pyrazole derivatives.
It can also be used in the total synthesis of bioactive compounds like echinoside A and salinosporamide A.

pictograms

GHS05

signalword

Danger

hcodes

H314

pcodes

P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338 + P310

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

supp_hazards

EUH014

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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