A9584
N-Acetoxy-N-acetyl-4-chlorobenzenesulfonamide
≥98%
Synonym(s):
O-Acetyl-N-(4-chlorophenylsulfonyl)acethydroxamic acid, HOPO
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About This Item
Empirical Formula (Hill Notation):
C10H10ClNO5S
CAS Number:
Molecular Weight:
291.71
PubChem Substance ID:
UNSPSC Code:
12352100
Beilstein/REAXYS Number:
5821854
MDL number:
assay
≥98%
form
flakes
storage temp.
2-8°C
SMILES string
CC(=O)ON(C(C)=O)S(=O)(=O)c1ccc(Cl)cc1
InChI
1S/C10H10ClNO5S/c1-7(13)12(17-8(2)14)18(15,16)10-5-3-9(11)4-6-10/h3-6H,1-2H3
InChI key
GWYBSWWLKXEDLB-UHFFFAOYSA-N
Application
Nitroxyl (HNO) releasing compound in neutral solution
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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J M Fukuto et al.
Biochemical and biophysical research communications, 187(3), 1367-1373 (1992-09-30)
N,O-Diacylated-N-hydroxyarylsulfonamides are capable of slowly releasing nitroxyl (HNO) by simple, non-enzymatic hydrolysis in Krebs solution at 37 degrees C. Release of nitric oxide (NO) was not seen. These compounds were also found to elicit vasorelaxation in rabbit thoracic aorta in
M J Lee et al.
Journal of medicinal chemistry, 35(20), 3648-3652 (1992-10-02)
In the preceding paper, analogs of chlorpropamide with an OMe substituent on the sulfonamide nitrogen were shown to inhibit aldehyde dehydrogenase (AlDH), and it was postulated that these compounds were bioactivated by O-demethylation to release nitroxyl (HN = O, nitrosyl