ALD00031
Biotin-PEG4-TPG hydrate
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About This Item
Empirical Formula (Hill Notation):
C29H42N6O9S
Molecular Weight:
650.74
PubChem Substance ID:
UNSPSC Code:
12352200
reaction suitability
reagent type: cross-linking reagent
SMILES string
O=CC(C1=CC=C(N2C=C(COCCOCCOCCOCCNC(CCCC[C@@H]3C4C(NC(N4)=O)CS3)=O)N=N2)C=C1)=O.O
InChI
1S/C29H40N6O8S.H2O/c36-18-25(37)21-5-7-23(8-6-21)35-17-22(33-34-35)19-43-16-15-42-14-13-41-12-11-40-10-9-30-27(38)4-2-1-3-26-28-24(20-44-26)31-29(39)32-28;/h5-8,17-18,24,26,28H,1-4,9-16,19-20H2,(H,30,38)(H2,31,32,39);1H2/t24?,26-,28?;/m1./s1
InChI key
ISXVHRHXXBUQMK-JOOSLKMSSA-N
Application
This compound is for specifically labeling arginines with biotin. This reagent contains a phenylglyoxyl group that reacts specifically with the guanidinyl group of arginine. The PEG linker improves aqueous solubility. After attachment to arginine the biotin can be used for capture by streptavidin. See the associated publication by Thompson et al. for more details about the compound.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Darren A Thompson et al.
Journal of peptide science : an official publication of the European Peptide Society, 22(5), 311-319 (2016-03-24)
A new class of arginine-specific bioconjugation reagents for protein labeling has been developed. This method utilizes a triazolyl-phenylglyoxal group on the probe molecule that reacts selectively with the guandinyl group of Arg residues in a protein or peptide. The reaction