A systematic vibrational spectroscopic assignment and analysis of benzohydrazide (BH) has been carried out by using FTIR and FT-Raman spectral data. The vibrational analysis were aided by electronic structure calculations--ab initio (RHF) and hybrid density functional methods (B3LYP and B3PW91)

Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer.

Daniel E Carvajal-Hausdorf et al.

Journal for immunotherapy of cancer, 5(1), 81-81 (2017-10-19)

Immunostimulatory therapies targeting immune-suppressive pathways produce durable responses in advanced solid tumors. Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting oxidoreductase that catalyzes the degradation of tryptophan to kynurenine. IDO induces immune tolerance by downregulating CD8+ and effector CD4+ T cell responses.

A simple turn-on fluorescent chemosensor based on Schiff base-terminated water-soluble polymer for selective detection of Al3+ in 100% aqueous solution.

Liping Bai et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 214, 436-444 (2019-02-27)

A simple water-soluble polymer PEGBHB based on polyethylene glycol bearing a Schiff base derivative moiety was successfully designed and synthesized. PEGBHB showed high selectivity and sensitivity towards Al3+ as a turn-on fluorescent chemosensor without influence by other competitive metal ions

Spectral and redox studies on mixed ligand complexes of cobalt(III) phenanthroline/bipyridyl and benzoylhydrazones, their DNA binding and antimicrobial activity.

S Srinivasan et al.

Journal of inorganic biochemistry, 99(3), 876-882 (2005-02-15)

Cobalt(III) complexes of the type [Co(N-N)2L](ClO4)2.H2O [where L=anionic form of para-substituted benzaldehyde-benzoylhydrazone (BHBX-); X=H, Me, OMe, OH, Cl or NO2; N-N=2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen)] have been synthesized and characterized through UV-Vis, IR, NMR and electrochemical studies. The IR spectral

High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.

Venkataswamy Sorna et al.

Journal of medicinal chemistry, 56(23), 9496-9508 (2013-11-19)

Lysine specific demethylase 1 (LSD1) plays an important role in regulating histone lysine methylation at residues K4 and K9 on histone H3 and is an attractive therapeutic target in multiple malignancies. Here we report a structure-based virtual screen of a

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Benzhydrazide

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